Results 91 to 100 of about 122,184 (292)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Comparing the effectiveness of testing methods in improving programs: the effect of variations in program quality [PDF]
, 1998 We compare the efficacy of different testing methods for improving the reliability of software. Specifically, we use modelling to compare “operational” testing, in which test cases are chosen according to their probability of occurring in actual use of ...
Pizza, M., Strigini, L.
core
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Line x Tester analysis for yield components and cercospora leaf spot resistance in brinjal (Solanum melongena L.) [PDF]
Electronic Journal of Plant Breeding, 2014 A line x tester analysis was made to assess the nature and extent of heterosis and combining ability using 36 eggplant hybrids along with their respective parents 15 parents (12 lines and 3 testers).
VenkataNaresh B.* A.K.Dubey *, P.K.Tiwari*, and M.R.Dabbas*
doaj
Electronic Journal of Plant Breeding, 2018 Combining ability analysis for yield and its component traits was carried out in rice through line x tester analysis of 20 hybrids developed by crossing 5 females with 4 male lines along with parents and checks at Agricultural Rice Research Station ...
Ch. Sreelakshmi and, P. Ramesh babu
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Software for physics of tau lepton decay in LHC experiments
, 2010 Software development in high energy physics experiments offers unique experience with rapidly changing environment and variety of different standards and frameworks that software must be adapted to.
Przedzinski, Tomasz
core
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source