Results 81 to 90 of about 122,184 (292)
Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2009 The objective of this study was to facilitate the selection in cotton breeding program and estimate the general combining ability (GCA) of the parents and specific combining ability (SCA) of hybrids considered for the development of high yielding and ...
Cetin KARADEMIR +3 more
doaj +1 more source
Tracing the early development of harmful algal blooms with the aid of Lagrangian coherent structures
, 2007 Several theories have been proposed to explain the development of harmful algal blooms (HABs) produced by the toxic dinoflagellate \emph{Karenia brevis} on the West Florida Shelf.
F. J. Beron-vera +4 more
core +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Electronic Journal of Plant Breeding, 2020 Eighteen hybrids generated from crossing six lines with three testers were studied along with their parents for combining ability and gene action involved in the expression of characters in barley to identify suitable parents and desirable hybrid ...
Anju Kumari, S.R. Vishwakarma and Yogendra Singh
doaj +1 more source
Electronic Journal of Plant Breeding, 2017 The present investigation was undertaken to study heterosis and explore its commercial utilization in desi cotton (G. arboreum L.) by using Line x Tester design with four genetic male sterile females and fifteen male parents. Out of sixty hybrids studied,
R.D. Vekariya +5 more
doaj +1 more source
Learning to Become an Expert: Deep Networks Applied To Super-Resolution Microscopy
, 2018 With super-resolution optical microscopy, it is now possible to observe molecular interactions in living cells. The obtained images have a very high spatial precision but their overall quality can vary a lot depending on the structure of interest and the
De Koninck, Paul +5 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source