Results 111 to 120 of about 3,416,725 (336)

Extensive horizontal gene transfer during Staphylococcus aureus co-colonization in vivo. [PDF]

, 2014
Staphylococcus aureus is a commensal and major pathogen of humans and animals. Comparative genomics of S. aureus populations suggests that colonization of different host species is associated with carriage of mobile genetic elements (MGE), particularly ...
Gould, KA, Lindsay, JA, Lloyd, DH, Loeffler, A, McCarthy, AJ, Witney, AA   +5 more
core   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Daughter of Self-Liberation: Lineage Position and Transmission in the Namthar of Do Dasel Wangmo [PDF]

, 2012
Scholarship regarding the complexity of lineage transmission within the Nyingma sect of Tibetan Buddhism is scant. The namthar, or “complete liberation story,” of Do Dasel Wangmo provides many details as to the variety of lineage transmissions that have ...
Michalsen, Ravenna Necara
core   +2 more sources

On the identity of broad-shelled mussels (Mollusca, Bivalvia, Mytilus) from the Dutch delta region [PDF]

, 2011
Late Quaternary (Eemian) deposits of the Netherlands contain shells that resemble those of living Mytilus galloprovincialis. Similar broad-shelled mytilids also occur in estuaries of the southwestern Netherlands together with slender individuals typical ...
Bos, M.M., Gittenberger, E., Groenenberg, D.S.J., Hoeksema, B.W., Hummel, H., Jansen, J.M., Raad, H., Rajagopal, S., Velde van der, G., Wesselingh, F.P.   +9 more
core   +3 more sources

Lineage-specific and single cell chromatin accessibility charts human hematopoiesis and leukemia evolution

Nature Genetics, 2016
We define the chromatin accessibility and transcriptional landscapes in 13 human primary blood cell types that span the hematopoietic hierarchy. Exploiting the finding that the enhancer landscape better reflects cell identity than mRNA levels, we enable '
M. Corces, Jason D. Buenrostro, Jason D. Buenrostro, Beijing Wu, Peyton Greenside, Steven M. Chan, J. Koenig, M. Snyder, Jonathan K. Pritchard, Jonathan K. Pritchard, Anshul B Kundaje, W. Greenleaf, R. Majeti, Howard Y. Chang   +13 more
semanticscholar   +1 more source

Genetic Isolation among Four Lineages of Silene nutans

Plant And Cell Physiology
Abstract Speciation is the process leading to the emergence of new species. While being usually progressive, it can sometimes be fast with rapid emergence of reproductive barriers leading to high level of reproductive isolation.
Postel, Zoé, Martin, Hélène, Roux, Camille, Godé, Cécile, Genete, Mathieu, Schmitt, Éric, Monnet, François, Vekemans, Xavier, Touzet, Pascal   +8 more
openaire   +2 more sources

Evidence of cryptic genetic lineages within Aedes notoscriptus (Skuse)

Infection, Genetics and Evolution, 2013
Aedes notoscriptus (Skuse), a mosquito from the southwest Pacific region including Australia, has been implicated as a vector of arboviruses, but its status as a species is unclear. To investigate the taxonomic situation, we assessed genetic variation and phylogenetic relationships among Ae.
Nancy M, Endersby, Vanessa L, White, Janice, Chan, Tim, Hurst, Gordana, Rašić, Adam, Miller, Ary A, Hoffmann   +6 more
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Evolution of microgastropods (Ellobioidea, Carychiidae): integrating taxonomic, phylogenetic and evolutionary hypotheses [PDF]

, 2013
BACKGROUND: Current biodiversity patterns are considered largely the result of past climatic and tectonic changes. In an integrative approach, we combine taxonomic and phylogenetic hypotheses to analyze temporal and geographic diversification of epigean (
Adrienne Jochum, Alexander M Weigand, Annette Klussmann-Kolb, Eugenia Zarza, Jan nges ar Schnitzler, Rajko Slapnik, Weigand, Alexander M   +6 more
core   +1 more source

Many, but not all, lineage-specific genes can be explained by homology detection failure

bioRxiv, 2020
Genes for which homologs can be detected only in a limited group of evolutionarily related species, called “lineage-specific genes,” are pervasive: essentially every lineage has them, and they often comprise a sizable fraction of the group’s total genes.
Caroline M. Weisman, A. Murray, S. Eddy
semanticscholar   +1 more source