Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
On the identity of broad-shelled mussels (Mollusca, Bivalvia, Mytilus) from the Dutch delta region [PDF]
, 2011 Late Quaternary (Eemian) deposits of the Netherlands contain shells that resemble those of living Mytilus galloprovincialis. Similar broad-shelled mytilids also occur in estuaries of the southwestern Netherlands together with slender individuals typical ...
Bos, M.M. +9 more
core +3 more sources
Genetic Isolation among Four Lineages of Silene nutans
Plant And Cell PhysiologyAbstract Speciation is the process leading to the emergence of new species. While being usually progressive, it can sometimes be fast with rapid emergence of reproductive barriers leading to high level of reproductive isolation.
Postel, Zoé +8 more
openaire +2 more sources
Evidence of cryptic genetic lineages within Aedes notoscriptus (Skuse)
Infection, Genetics and Evolution, 2013 Aedes notoscriptus (Skuse), a mosquito from the southwest Pacific region including Australia, has been implicated as a vector of arboviruses, but its status as a species is unclear. To investigate the taxonomic situation, we assessed genetic variation and phylogenetic relationships among Ae.
Nancy M, Endersby +6 more
openaire +2 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Phylogenomic analysis of lactobacillus curvatus reveals two lineages distinguished by genes for fermenting plant-derived carbohydrates [PDF]
, 2018 Lactobacillus curvatus is a lactic acid bacterium encountered in many different types of fermented food (meat, seafood, vegetables, and cereals). Although this species plays an important role in the preservation of these foods, few attempts have been ...
Chaillou, Stéphane +5 more
core +3 more sources
Retracing lineage history: time to emphasize genetic turnover [PDF]
Trends in Microbiology, 2021 Andrew K. Watson +2 more
openaire +2 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Mitochondrial DNA Variation of Feral Honey Bees (Apis mellifera L.) from Utah (USA)
Journal of Apicultural Science, 2018 A study was conducted on the mitochondrial DNA genetic diversity of feral colonies and swarms of Apis mellifera from ten counties in Utah by sequencing the intergenic region of the cytochrome oxidase (COI-COII) gene region.
Cleary Dylan +5 more
doaj +1 more source
Pseudobarbus outeniqua sp. nov., a new redfin species (Teleostei, Cyprinidae) from the Cape Fold Ecoregion of South Africa [PDF]
ZooKeysPrevious DNA-based studies identified four genetic lineages within Pseudobarbus afer: (i) the Mandela lineage confined to the Sundays, Swartkops, and Baakens river systems, (ii) the Krom lineage endemic to the Krom River system, (iii) the St Francis ...
Fatah Zarei +3 more
doaj +3 more sources