Results 71 to 80 of about 534,399 (300)

GDNF‐RET signaling drives pulmonary neuroendocrine cell hyperplasia and allergic airway inflammation

FEBS Letters, EarlyView.
A neuroimmune interaction centered on the PNEC‐ILC2 axis in an asthma model. PNEC‐derived CGRP activates nearby ILC2s, which then release cytokines, including IL‐5 and IL‐13. These cytokines promote eosinophil and macrophage infiltration. Subsequently, GDNF produced by these cells induces PNEC hyperplasia via the GDNF receptors, RET and GFRα1 ...
Tasuku Kawano, Erina Ike, Suguru Okada, Tomoko Takahashi   +3 more
wiley   +1 more source

Continent-wide view of genomic diversity and divergence in the wolves of Asia

Communications Biology
Grey wolves (Canis lupus) in Asia hold most of the species’ genetic diversity and many endangered populations. However, a clear understanding of the evolutionary history of wolves in Asia is lacking, hindering their conservation. We used 98 whole genomes
Lauren M. Hennelly, Bárbara R. Parreira, Ash Noble, Camilla H. Scharff-Olsen, M. Çisel Kemahlı Aytekin, Çağan H. Şekercioğlu, Pavel Kosintsev, Ladislav Paule, Pavel Hulva, Hans K. Stenøien, Bilal Habib, Hira Fatima, Ghulam Sarwar, Samara P. El-Haddad, Alexandra Youssef, Frank Hailer, Xin Sun, Nuno Filipes Gomes Martins, M. Thomas P. Gilbert, Benjamin N. Sacks, Mikkel-Holger S. Sinding, Shyam Gopalakrishnan   +21 more
doaj   +1 more source

Draft genome sequences of seven isolates of Phytophthora ramorum EU2 from Northern Ireland

Genomics Data, 2015
Here we present draft-quality genome sequence assemblies for the oomycete Phytophthora ramorum genetic lineage EU2. We sequenced genomes of seven isolates collected in Northern Ireland between 2010 and 2012. Multiple genome sequences from P.
Lourdes de la Mata Saez, Alistair R. McCracken, Louise R. Cooke, Paul O'Neill, Murray Grant, David J. Studholme   +5 more
doaj   +1 more source

The role of landscape evolution in the genetic diversification of a stream fish Sarcocheilichthys parvus from Southern China

Frontiers in Genetics, 2023
Sarcocheilichthys parvus (Cypriniformes: Gobionidae) is a stream fish which is endemic to sub-tropical coastal drainages in southern China, thus offering a valuable model for understanding how genetic divergence arises in stream-adapting freshwater ...
Mingyue Li, Xishu Yang, Xiaomin Ni, Cuizhang Fu   +3 more
doaj   +1 more source

Genetic dissection of clonal lineage relationships with hydroxytamoxifen liposomes [PDF]

Nature Communications, 2018
AbstractTargeted genetic dissection of tissues to identify precise cell populations has vast biological and therapeutic applications. Here we develop an approach, through the packaging and delivery of 4-hydroxytamoxifen liposomes (LiTMX), that enables localized induction of CreERT2 recombinase in mice.
Ryan C. Ransom, Deshka S. Foster, Ankit Salhotra, Ruth Ellen Jones, Clement D. Marshall, Tripp Leavitt, Matthew P. Murphy, Alessandra L. Moore, Charles P. Blackshear, Elizabeth A. Brett, Derrick C. Wan, Michael T. Longaker   +11 more
openaire   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Genetic Engineering of Human Embryonic Stem Cells for Precise Cell Fate Tracing during Human Lineage Development

Stem Cell Reports, 2018
Summary: It is highly desirable to specify human developmental principles in an appropriate human model with advanced genetic tools. However, genetically engineering human cells with lineage-tracing systems has not been achieved.
Zhenyu Chen, Xudong Ren, Xiangjie Xu, Xiaojie Zhang, Yi Hui, Zhongliang Liu, Lei Shi, Yujiang Fang, Lin Ma, Yang Liu, Daniel Terheyden-Keighley, Ling Liu, Xiaoqing Zhang   +12 more
doaj   +1 more source

How to infer relative fitness from a sample of genomic sequences

, 2013
Mounting evidence suggests that natural populations can harbor extensive fitness diversity with numerous genomic loci under selection. It is also known that genealogical trees for populations under selection are quantifiably different from those expected
Dayarian, Adel, Shraiman, Boris I
core   +1 more source

Extensive horizontal gene transfer during Staphylococcus aureus co-colonization in vivo. [PDF]

, 2014
Staphylococcus aureus is a commensal and major pathogen of humans and animals. Comparative genomics of S. aureus populations suggests that colonization of different host species is associated with carriage of mobile genetic elements (MGE), particularly ...
Gould, KA, Lindsay, JA, Lloyd, DH, Loeffler, A, McCarthy, AJ, Witney, AA   +5 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source