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Genetic lineage tracing identifies endocardial origin of liver vasculature
Nature Genetics, 2016The hepatic vasculature is essential for liver development, homeostasis and regeneration, yet the developmental program of hepatic vessel formation and the embryonic origin of the liver vasculature remain unknown. Here we show in mouse that endocardial cells form a primitive vascular plexus surrounding the liver bud and subsequently contribute to a ...
Hui, Zhang +11 more
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Introduction: The Malecot Lineage in Population Genetics
2002Abstract Gustave Malecot (1911-1998) was one of the pioneers of theoretical population genetics. He introduced some of the fundamental methods and principles of the field, yet because he wrote most of his papers in French and because some of his methods were developed long before they could be applied to data, Malecot’s work has been ...
Michel Veuille, Montgomery Slatkin
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Genetic Lineages of Mycobacterium tuberculosis Isolates in Isfahan, Iran
Current Microbiology, 2016In this study, we aimed to identify the genetic lineages of Mycobacterium tuberculosis isolates in Isfahan via the mycobacterial interspersed repetitive-unit-variable number tandem repeat typing method based on 15 loci. Forty-nine M. tuberculosis isolates were collected between 2013 and 2015 from Tuberculosis patients in Mollahadi Sabzevari ...
Fatemeh, Riyahi Zaniani +6 more
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From cell lineage to developmental genetics.
History and philosophy of the life sciences, 1998One of the bases of developmental genetics resides in the alliance of clonal analysis and genetic analysis. But the study of cell lineage--cells which have their genealogical relationship--and the study of the cellular labelled progeny, have their own history. We have tried to follow it since its foundation with C.O. Whitman (1878) and E.B.
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Genetic lineage, bone mass, and physical activity in mice
Bone, 1995Five strains of inbred mice were found to have variations in bone mass although they were similar in body weight. Two of these strains, C57BL/6J and A/J, were studied in greater detail and the former had more bone in both femur and tibia. The increased bone mass was associated with larger quadriceps muscles in the C57BL/6J animals when measured at 18 ...
M, Kaye, R P, Kusy
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Genetic lineage tracing of resident stem cells by DeaLT
Nature Protocols, 2018Unraveling the fates of resident stem cells during tissue regeneration is an important objective in clinical and basic research. Genetic lineage tracing based on Cre-loxP recombination provides an effective strategy for inferring cell fate and cell conversion in vivo.
Lingjuan He +9 more
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Learning and Lineage Selection in Genetic Algorithms
Proceedings. IEEE SoutheastCon, 2005., 2005Lineage selection is a process by which traits that are not directly assessed by the fitness function can evolve. Reported here is an investigation of the effects of individual learning on the evolution of one such trait, self-adaptive mutation rates. It is found that the efficacy of the learning mechanism employed (its potential to increase individual
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Identification of genetically aberrant cell lineages in Wilms' tumors
Genes, Chromosomes and Cancer, 1994AbstractMost Wilms' tumors contain several predominant cell types, of which a primitive blastemal population is often the most prominent. Other typical components include undifferentiated mesenchymal and epithelial cells, but it has not been demonstrated that these components are neoplastic.
Weremowicz, S +5 more
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Genetic Lineage Tracing of Lymphatic Endothelial Cells in Mice
2018Lineage tracing allows for identification of all progeny produced by a single cell or groups of cells and can thus be used to assess developmental fate of cells. Here we focus on one of the most widely used lineage tracing approaches that utilize the Cre/loxP system for site-specific genetic recombination in studying the developmental origins of ...
Ines, Martinez-Corral, Taija, Makinen
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Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England
Nature, 2021Erik M Volz +2 more
exaly