Genomic insights into the population structure, antimicrobial resistance, and virulence of <i>Brachyspira hyodysenteriae</i> from diverse geographical regions. [PDF]
Hakimi M+10 more
europepmc +1 more source
Tracing and Capturing the Epiblast Pluripotency of Sheep Preimplantation Embryos
This study performs a comprehensive single‐cell transcriptome analysis of sheep embryos from embryonic (E) day 1 to E14 to elucidate the mechanism of early lineage specification and the pluripotency changes (naïve, formative, and primed) of epiblast.
Jinying Zhang+28 more
wiley +1 more source
Genetic diversity and novel haplotypes of <i>Apis mellifera jemenitica</i> on the Arabian Peninsula: insights from mtDNA markers. [PDF]
Alsharhi M+3 more
europepmc +1 more source
Integrated single‐cell transcriptomic and metabolomic analyses reveal that MYC‐driven glycolysis activates the PI3K‐AKT‐FOXO1 pathway, disrupting Th17/Treg balance and promoting uveitis. MYC inhibition restores immune homeostasis and alleviates disease symptoms.
He Li+11 more
wiley +1 more source
Evolutionary Origin and Genetic Diversity of the Pannonian Ecotype of <i>Apis mellifera carnica</i> Colonies in Hungary Based on Mitochondrial DNA and Microsatellite Markers. [PDF]
Balazs R+6 more
europepmc +1 more source
Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang+6 more
wiley +1 more source
Diverse Genetic Mechanisms Enable Pseudomonas syringae to Rapidly Overcome Effector-Triggered Immunity. [PDF]
Newfeld J+5 more
europepmc +1 more source
In the tripartite‐species model, Drosophila larvae stimulate lactate production through excreting digestion enzymes. S. marcescens population senses a cue of lactate and tends to diverge into virulent and reduced virulence subclusters with remarkable heterogeneity to metabolize carbon metabolism and counter colonization resistance, giving a fitness ...
Sheng Zhang+10 more
wiley +1 more source
Understanding the epidemiology and pathogenesis of Mycobacterium tuberculosis with non-redundant pangenome of epidemic strains in China. [PDF]
Zhou Y+11 more
europepmc +1 more source
Reinforcing Stromal Cell Spheroid Through Red‐Light Preconditioning for Advanced Vascularization
This study presents a novel approach to enhance stromal cell therapy for myocardial infarction by combining OLED‐based photobiomodulation (OPBM) preconditioning with 3D spheroid culture of hADSCs. The engineered spheroids improve angiogenesis, arterialization, and cardiac function in vivo, offering a next‐generation therapeutic strategy to overcome ...
Yu‐Jin Kim+12 more
wiley +1 more source