Results 171 to 180 of about 5,206,546 (317)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Linear Programming [PDF]

Operations Research, 1987
openaire   +1 more source

Psychometric functions for temporal discrimination: Duration or log duration? [PDF]

Behav Res Methods
García-Pérez MA, Alcalá-Quintana R.
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Linear Functions - Budget Lines

, 2010
These films look at the use of linear functions to examine the spending options for a university student (duration 11 minutes 30 seconds). Part of a series of films from the METAL (Mathematics for Economics: enhancing Teaching and Learning) project that ...
METAL (Mathematics for Economics: enhancing Teaching and Learning)
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Summary - Solving Linear Equations

, 2010
This film is a summary of the concept of solving linear equations. (Duration 33 seconds). Part of a series of films from the METAL (Mathematics for Economics: enhancing Teaching and Learning) project that examines spending options in a number of contexts,
METAL (Mathematics for Economics: enhancing Teaching and Learning)
core  

Estimating multivariate longitudinal trajectories using mixed-effects models with crossed random effects. [PDF]

Behav Res Methods
Martínez-Huertas JÁ, Ferrer E.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Summary on Linear Functions

, 2010
This film is a summary of the significance of linear functions in economics. (Duration 54 seconds). Part of a series of films from the METAL (Mathematics for Economics: enhancing Teaching and Learning) project that examines spending options in a number ...
METAL (Mathematics for Economics: enhancing Teaching and Learning)
core