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Denoising two-photon calcium imaging data. [PDF]
PLoS ONE, 2011 Two-photon calcium imaging is now an important tool for in vivo imaging of biological systems. By enabling neuronal population imaging with subcellular resolution, this modality offers an approach for gaining a fundamental understanding of brain anatomy ...
Wasim Q Malik +3 more
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Calcium imaging for analgesic drug discovery
Neurobiology of Pain, 2022 Somatosensation and pain are complex phenomena involving a rangeofspecialised cell types forming different circuits within the peripheral and central nervous systems.
Federico Iseppon +2 more
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From calcium imaging to graph topology
Harvard Data Science Review, 2022 Abstract Systems neuroscience is facing an ever-growing mountain of data. Recent advances in protein engineering and microscopy have together led to a paradigm shift in neuroscience; using fluorescence, we can now image the activity of every neuron through the whole brain of behaving animals.
Ann S. Blevins +3 more
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Frontiers in Cell and Developmental Biology, 2021 X-linked hypophosphatemia (XLH) is the most common form of genetic rickets. Mainly diagnosed during childhood because of growth retardation and deformities of the lower limbs, the disease affects adults with early enthesopathies and joint structural ...
Axelle Cauliez +16 more
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Genetically engineered mice for combinatorial cardiovascular optobiology
eLife, 2021 Optogenetic effectors and sensors provide a novel real-time window into complex physiological processes, enabling determination of molecular signaling processes within functioning cellular networks. However, the combination of these optical tools in mice
Frank K Lee +14 more
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Growth hormone treatment improves final height in children with X-linked hypophosphatemia
Orphanet Journal of Rare Diseases, 2022 Background/aim Despite optimal conventional treatment (oral phosphate supplements and active vitamin D analogs), about 40–50% of children with well-controlled X-linked hypophosphatemia (XLH) show linear growth failure, making them less likely to achieve ...
Julia André +8 more
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Frontiers in Cell and Developmental Biology, 2020 X-linked hypophosphatemia (XLH) is characterized by rickets and osteomalacia, caused by inactivating mutations in the Phosphate-regulating endopeptidase homolog X-linked (PHEX) gene.
Carole-Anne Faraji-Bellée +19 more
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Recent Advances of Calcium Carbonate Nanoparticles for Biomedical Applications
Bioengineering, 2022 Calcium carbonate nanoparticles have been widely used in biomedicine due to their biocompatibility and biodegradability. Recently, calcium carbonate nanoparticles are largely integrated with imaging contrast and therapeutic agents for various imaging and
Pengxuan Zhao +4 more
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A hardware system for real-time decoding of in vivo calcium imaging data
eLife, 2023 Epifluorescence miniature microscopes (‘miniscopes’) are widely used for in vivo calcium imaging of neural population activity. Imaging data are typically collected during a behavioral task and stored for later offline analysis, but emerging techniques ...
Zhe Chen +9 more
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Imaging Calcium in Neurons [PDF]
Neuron, 2012 Calcium ions generate versatile intracellular signals that control key functions in all types of neurons. Imaging calcium in neurons is particularly important because calcium signals exert their highly specific functions in well-defined cellular subcompartments. In this Primer, we briefly review the general mechanisms of neuronal calcium signaling.
Grienberger, Christine, Konnerth, Arthur
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