Results 1 to 10 of about 359,534 (258)
Inferring spikes from calcium imaging in dopamine neurons.
PLoS ONE, 2021 Calcium imaging has led to discoveries about neural correlates of behavior in subcortical neurons, including dopamine (DA) neurons. However, spike inference methods have not been tested in most populations of subcortical neurons.
Weston Fleming +4 more
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Mesoscale calcium imaging in vivo: evolution and contribution to developmental neuroscience
Frontiers in Neuroscience, 2023 Calcium imaging is commonly used to visualize neural activity in vivo. In particular, mesoscale calcium imaging provides large fields of view, allowing for the simultaneous interrogation of neuron ensembles across the neuraxis.
Teresa Guillamón-Vivancos +4 more
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Calcium imaging for analgesic drug discovery
Neurobiology of Pain, 2022 Somatosensation and pain are complex phenomena involving a rangeofspecialised cell types forming different circuits within the peripheral and central nervous systems.
Federico Iseppon +2 more
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Fast Calcium Imaging with Optical Sectioning via HiLo Microscopy.
PLoS ONE, 2015 Imaging intracellular calcium concentration via reporters that change their fluorescence properties upon binding of calcium, referred to as calcium imaging, has revolutionized our way to probe neuronal activity non-invasively.
Marcel A Lauterbach +4 more
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Calcium Imaging of AM Dyes Following Prolonged Incubation in Acute Neuronal Tissue.
PLoS ONE, 2016 Calcium-imaging is a sensitive method for monitoring calcium dynamics during neuronal activity. As intracellular calcium concentration is correlated to physiological and pathophysiological activity of neurons, calcium imaging with fluorescent indicators ...
Morven Cameron +6 more
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Calcium Imaging and the Curse of Negativity [PDF]
Frontiers in Neural Circuits, 2020 The imaging of neuronal activity using calcium indicators has become a staple of modern neuroscience. However, without ground truths, there is a real risk of missing a significant portion of the real responses. Here, we show that a common assumption, the non-negativity of the neuronal responses as detected by calcium indicators, biases all levels of ...
Gilles Vanwalleghem +2 more
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Frontiers in Cell and Developmental Biology, 2021 X-linked hypophosphatemia (XLH) is the most common form of genetic rickets. Mainly diagnosed during childhood because of growth retardation and deformities of the lower limbs, the disease affects adults with early enthesopathies and joint structural ...
Axelle Cauliez +16 more
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Genetically engineered mice for combinatorial cardiovascular optobiology
eLife, 2021 Optogenetic effectors and sensors provide a novel real-time window into complex physiological processes, enabling determination of molecular signaling processes within functioning cellular networks. However, the combination of these optical tools in mice
Frank K Lee +14 more
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Growth hormone treatment improves final height in children with X-linked hypophosphatemia
Orphanet Journal of Rare Diseases, 2022 Background/aim Despite optimal conventional treatment (oral phosphate supplements and active vitamin D analogs), about 40–50% of children with well-controlled X-linked hypophosphatemia (XLH) show linear growth failure, making them less likely to achieve ...
Julia André +8 more
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Imaging Calcium in Neurons [PDF]
Neuron, 2012 Calcium ions generate versatile intracellular signals that control key functions in all types of neurons. Imaging calcium in neurons is particularly important because calcium signals exert their highly specific functions in well-defined cellular subcompartments. In this Primer, we briefly review the general mechanisms of neuronal calcium signaling.
Grienberger, Christine, Konnerth, Arthur
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