Results 61 to 70 of about 1,087,987 (259)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
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M-ary Rank Classifier Combination: A Binary Linear Programming Problem
Entropy, 2019 The goal of classifier combination can be briefly stated as combining the decisions of individual classifiers to obtain a better classifier. In this paper, we propose a method based on the combination of weak rank classifiers because rankings contain ...
Vincent Vigneron, Hichem Maaref
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
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Linear combination methods for prediction of drug skin permeation
ADMET and DMPK, 2015 Many in-vitro methods for prediction of skin permeability have been reported in literature. Cerasome electrokinetic chromatography is one of the most sophisticated approaches representing a maximum level of similarity to the lipid phase of the stratum ...
Stefan Scheler, Alfred Fahr, Xiangli Liu
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Approximation analysis of ontology learning algorithm in linear combination setting
Journal of Cloud Computing: Advances, Systems and Applications, 2020 In the past ten years, researchers have always attached great importance to the application of ontology to its relevant specific fields. At the same time, applying learning algorithms to many ontology algorithms is also a hot topic. For example, ontology
Wei Gao, Yaojun Chen
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FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Estimating Stochastic Linear Combination of Non-Linear Regressions
Proceedings of the AAAI Conference on Artificial Intelligence, 2020 In this paper we study the problem of estimating stochastic linear combination of non-linear regressions, which has a close connection with many machine learning and statistical models such as non-linear regressions, the Single Index, Multi-index, Varying Coefficient Index Models and Two-layer Neural Networks. Specifically, we first show that with some
Di Wang 0015 +4 more
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
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The Multiplicative Perturbation of Group Invertible Operators in Banach Space
MathematicsIn this paper, the multiplicative perturbation of group invertible operators is studied. We first establish necessary and sufficient conditions for the existence, along with explicit expressions, of the group inverse under multiplicative perturbation ...
Saijie Chen +3 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
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