Results 141 to 150 of about 25,937,483 (340)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Multi-objective controller design for bi-linear stochastic systems via sliding mode control concept

, 2012
[[abstract]]A sliding mode controller u(t) is designed to achieve the following three objectives simultaneously: eigenvalue placement, H‘ norm constraint, and individual state variance constraint for bi-linear stochastic systems.
Chang, K. Y. ; Lu, Chien-Yu; Shih, C. H. ; Chen, P. C.
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Combining learning and control in linear systems

European Journal of Control
6 pages, 1 figure.
openaire   +4 more sources

The Optimal Sampling Pattern for Linear Control Systems

IEEE Transactions on Automatic Control, 2014
Enrico Bini, G. Buttazzo
semanticscholar   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Memory‐based event‐triggered control for networked control system under cyber‐attacks

IET Control Theory & Applications
This article focuses on the problem of stability for a class of linear networked control systems (NCSs) subjected to network communication delays and random deception attacks.
Noureddine Nafir, Abdel Mouneim Khemissat, Mohamed Emad Farrag, Mohamed Rouamel   +3 more
doaj   +1 more source

THE NORM OPTIMAL CONTROL PROBLEM FOR STOCHASTIC LINEAR CONTROL SYSTEMS

, 2015
Yanqing Wang, Can Zhang
semanticscholar   +1 more source