Results 201 to 210 of about 25,937,483 (340)

Multilayer perceptron neural network approach for power quality improvement in a grid integrated PV and electric vehicle systems. [PDF]

PLoS One
Das SR, Sabhahit JN, Patro KAK, Acharya DP, Mohanty A, Cuce E.   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Integrated photonic polarization synthesizer and analyzer. [PDF]

Light Sci Appl
Valdez CG, Miller AJ, Kroo AR, Roques-Carmes C, Miller DAB, Solgaard O.   +5 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Enhanced detection of low-level viremia by cobas 5800/6800 testing systems: a multi-center evaluation and clinical calibration study in China. [PDF]

Front Cell Infect Microbiol
Wang Y, Li J, Pan P, Liu J, Zhang X, Han D, Wang M, Li T, Jin C.   +8 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Performance improvement of AC servo motor PID control with backlash compensation using a Hybrid Genetic Algorithm-Grey Wolf Optimization approach. [PDF]

Sci Rep
Fayad SA, Shaban M, Attia M, Abdelwahab SAM.   +3 more
europepmc   +1 more source

Canonical forms for positive discrete-time linear control systems☆

, 2000
R. Bru, S. Romero, E. Sánchez
semanticscholar   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Ultrahigh-molecular-weight tadpole polymers with statistically symmetric head-to-tail geometry: the key topological intermediate bridging linear and cyclic architectures. [PDF]

Chem Sci
Liang W, Gong J, Deng Y, He W, Wang Y, Zhu M, Guan X, Yan ZC, Chen Z, Li X, Song Y, Li L, Zhang W.   +12 more
europepmc   +1 more source