Results 51 to 60 of about 1,213,415 (277)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

A New Analytical Procedure for Solving the Non-Linear Differential Equation Arising in the Stretching Sheet Problem

open access: yesInternational Journal of Applied Mechanics and Engineering, 2013
The paper discusses a new analytical procedure for solving the non-linear boundary layer equation arising in a linear stretching sheet problem involving a Newtonian/non-Newtonian liquid. On using a technique akin to perturbation the problem gives rise to
P.G. Siddheshwar   +2 more
doaj   +1 more source

Picard-Fuchs equations for Feynman integrals

open access: yes, 2013
We present a systematic method to derive an ordinary differential equation for any Feynman integral, where the differentiation is with respect to an external variable. The resulting differential equation is of Fuchsian type. The method can be used within
Müller-Stach, Stefan   +2 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Nonlinear differential equation with first order partial derivatives

open access: yesВестник КазНУ. Серия математика, механика, информатика, 2018
The asymptotic behavior of solutions of a nonlinear differential equation with first-order partial derivatives solved with respect to one of the derivatives is investigated.
T. М. Aldibekov, M. M. Aldazharova
doaj   +1 more source

Mean-Field Stochastic Linear Quadratic Optimal Control Problems: Closed-Loop Solvability

open access: yes, 2016
An optimal control problem is studied for a linear mean-field stochastic differential equation with a quadratic cost functional. The coefficients and the weighting matrices in the cost functional are all assumed to be deterministic.
Li, Xun, Sun, Jingrui, Yong, Jiongmin
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Euler Type Half-Linear Differential Equation with Periodic Coefficients

open access: yesAbstract and Applied Analysis, 2013
We investigate oscillatory properties of the perturbed half-linear Euler differential equation. We show that the results of the recent paper by O. Došlý and H.
Ondřej Došlý, Hana Funková
doaj   +1 more source

Numerical integration of the boundary value problems for the second order nonlinear ordinary differential equations of an arbitrary structure using an iterative procedure

open access: yesVestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2016
An iterative procedure for numerical integration of boundary-value problems for nonlinear ordinary differential equations of the second order of arbitrary structure is suggested.
Vladimir N Maklakov
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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