Results 61 to 70 of about 2,088,895 (372)

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

Nonlinear differential equation with first order partial derivatives

open access: yesВестник КазНУ. Серия математика, механика, информатика, 2018
The asymptotic behavior of solutions of a nonlinear differential equation with first-order partial derivatives solved with respect to one of the derivatives is investigated.
T. М. Aldibekov, M. M. Aldazharova
doaj   +1 more source

Gravitating fluids with Lie symmetries

open access: yes, 2010
We analyse the underlying nonlinear partial differential equation which arises in the study of gravitating flat fluid plates of embedding class one. Our interest in this equation lies in discussing new solutions that can be found by means of Lie point ...
A M Msomi   +9 more
core   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Reproducing Kernel Space Method for the Solution of Linear Fredholm Integro-Differential Equations and Analysis of Stability

open access: yesAbstract and Applied Analysis, 2012
We present a numerical method to solve the linear Fredholm integro-differential equation in reproducing kernel space. A simple algorithm is given to obtain the approximate solutions of the equation. Through the comparison of approximate and true solution,
Xueqin Lv, Yue Gao
doaj   +1 more source

Constructive factorization of LPDO in two variables

open access: yes, 2005
We study conditions under which a partial differential operator of arbitrary order $n$ in two variables or ordinary linear differential operator admits a factorization with a first-order factor on the left.
A. Loewy   +8 more
core   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

open access: yesFEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre   +4 more
wiley   +1 more source

On the local linearization of differential equations [PDF]

open access: yesProceedings of the American Mathematical Society, 1963
1. Consider the autonomous system of real, nonlinear differential equations (1.1) x' = Ex+F(x), where F(I x)= o(IxI) as x -0, x is a (Euclidean) vector, F(x) a smooth vector-valued function of x, and E a constant matrix with eigenvalues el, e2, -satisfying (1.2) Re ej 5 0.
openaire   +2 more sources

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

H\^older continuity of solutions of second-order non-linear elliptic integro-differential equations

open access: yes, 2010
This paper is concerned with H\"older regularity of viscosity solutions of second-order, fully non-linear elliptic integro-differential equations. Our results rely on two key ingredients: first we assume that, at each point of the domain, either the ...
Barles, Guy   +2 more
core   +3 more sources

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