Results 81 to 90 of about 1,073,247 (330)

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

open access: yesMolecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

On a linear system of differential equations

open access: yesJournal of Mathematics, Mechanics and Computer Science, 2019
The linear systems of partial differential equations of the first order with the identical main partsis considered. Аpplying the well-known relation between a normal system of ordinary differentialequations and a linear system of partial differential equations of the first order with the samemain parts, the existence of integral basis of a linear ...
M. M. Aldazharova, T. М. Aldibekov
openaire   +4 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Invariance of Hyers-Ulam stability of linear differential equations and its applications

open access: yes, 2015
We prove that the generalized Hyers-Ulam stability of linear differential equations of nth order (defined on I) is invariant under any monotone one-to-one correspondence τ:I→J$\tau: I \to J$ which is n times continuously differentiable.
Ginkyu Choi, Soon-Mo Jung
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Adjoint systems and Green functionals for second-order linear integro-differential equations with nonlocal conditions

open access: yesElectronic Journal of Differential Equations, 2015
In this work, we generalize so called Green's functional concept in literature to second-order linear integro-differential equation with nonlocal conditions. According to this technique, a linear completely nonhomogeneous nonlocal problem for a second-
Ali Sirma
doaj  

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

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