Results 91 to 100 of about 5,049,567 (284)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
On Fundamental Solution for Autonomous Linear Retarded Functional Differential Equations
, 2020 This document focuses attention on the fundamental solution of an autonomous linear retarded functional differential equation (RFDE) along with its supporting cast of actors: kernel matrix, characteristic matrix, resolvent matrix; and the Laplace ...
Clement McCalla
core +1 more source
For a correlation between a class of second order linear differential equations and a class of systems of first order differential equations [PDF]
, 2020 In this paper, a class of second order linear differential equations and a class of systems of first order differential equations are considered.
Piperevski, Boro, Zlatanovska, Biljana
core +1 more source
Uniform exponential stability of linear periodic systems in a Banach space
Electronic Journal of Differential Equations, 2001 This article is devoted to the study of linear periodic dynamical systems, possessing the property of uniform exponential stability. It is proved that if the Cauchy operator of these systems possesses a certain compactness property, then the asymptotic ...
David N. Cheban
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Prabhakar-type linear differential equations with variable coefficients
, 2022 Linear differential equations with variable coefficients and Prabhakar-type operators featuring Mittag-Leffler kernels are solved. In each case, the unique solution is constructed explicitly as a convergent infinite series involving compositions of ...
Fernandez, Arran +2 more
core
New Oscillation Results for Third-Order Half-Linear Neutral Differential Equations
, 2020 The main purpose of this paper is to obtain criteria for the oscillation of all solutions of a third-order half-linear neutral differential equation.
K. S. Vidhyaa +2 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Uniform exponential stability of linear almost periodic systems in Banach spaces
Electronic Journal of Differential Equations, 2000 This article is devoted to the study linear non-autonomous dynamical systems possessing the property of uniform exponential stability. We prove that if the Cauchy operator of these systems possesses a certain compactness property, then the uniform ...
David N. Cheban
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source