Results 71 to 80 of about 279,382 (273)

Mesoscale Recovery of Microglial and Neuronal Dynamics After Craniotomy Across Wide Cortex in Transgenic Mice

Advanced Science, EarlyView.
This study employs longitudinal fluorescence imaging in transgenic mice to map post‐craniotomy cortical recovery. We identify distinct neuroimmune recovery phases: microglial structural inflammation peaks at ∼10 days, neuronal structural intensity peaks at ∼14 days and correlates with microglial activity, and functional network modularity is most ...
Guihua Xiao, Zhilei Wang, Pengchang Zheng, Jingyu Xie, Yangzhen Wang, Yun Chen, Zilin Wang, Ao Li, Minghuan Wang, Quanbo Ji, Can Gao, Di Yao, Lingbo Li, Jiangbei Cao   +13 more
wiley   +1 more source

Hierarchical Summary Statistics Encoding Across Primary Visual and Posterior Parietal Cortices

Advanced Science, EarlyView.
This study shows that mouse V1 simultaneously encodes the ensemble mean and variance of motion, providing a robust summary‐statistic representation that persists despite single‐neuron variability. These signals propagate to PPC, where they are transformed into abstract category representations during decision making.
Young‐Beom Lee, Oliver James, Gaeun Jung, Doyun Lee, Yee‐Joon Kim   +4 more
wiley   +1 more source

Methylation Linear Discriminant Analysis (MLDA) for identifying differentially methylated CpG islands

BMC Bioinformatics, 2008
Background Hypermethylation of promoter CpG islands is strongly correlated to transcriptional gene silencing and epigenetic maintenance of the silenced state. As well as its role in tumor development, CpG island methylation contributes to the acquisition
Vass J Keith, Yan Pearlly, Huang Tim HM, Zeller Constanze, Graham Janet, Teodoridis Jens M, Dai Wei, Brown Robert, Paul Jim   +8 more
doaj   +1 more source

PM10 Impairs CD56dim NK Cell Cytotoxicity via FNBP1 Suppression to Exacerbate Rheumatoid Arthritis: Insights from Multimodal Multi‐Omics

Advanced Science, EarlyView.
This study, through multi‐omics approaches and animal models, revealed that air pollutant PM10 exacerbates the progression of rheumatoid arthritis (RA) by suppressing FNBP1 expression and impairing the cytotoxic function of CD56dim NK cells. The “PM10–FNBP1–NK cells” axis provided novel insights into the environmental pathogenesis of RA and suggested ...
Runhan Zhao, Qinyang Zhang, Yu Jiang, Dagang Tang, Xiao Qu, Jun Zhang, Yi Chen, Weixia Duan, Tao Li, Zhengwei Cai, Yanran Huang, Xiaoji Luo   +11 more
wiley   +1 more source

PENGENALAN WAJAH MENGGUNAKAN METODE LINEAR DISCRIMINANT ANALYSIS DAN K NEAREST NEIGHBOR

Jurnal Informatika, 2017
Pengenalan wajah merupakan sistem biometrika yang banyak digunakan untuk pengenalan individu pada penggunaan mesin absensi atau akses kontrol. Hal ini karena wajah merupakan salah satu ciri biometrika yang paling umum digunakan untuk mengenali seseorang.
Fandiansyah Fandiansyah, Jayanti Yusmah Sari, Ika Purwanti Ningrum   +2 more
doaj   +1 more source

Inulin‐Based Oral Chemotherapy Modulates Gut Microbiota and Immune Microenvironment through Inhibition of Neutrophil Extracellular Trap Formation for Improving Cancer Therapy

Advanced Science, EarlyView.
Schematic representation of ZIF‐8@OXA@inulin for cancer immunotherapy. Synthesis of ZIF‐8@OXA@inulin. Augmentation of pyroptosis, regulation of gut microbiota, and inhibition of NETs formation by ZIF‐8@OXA@inulin‐mediated comprehensive strategy for antitumor immune response. ABSTRACT Despite the potential of chemoimmunotherapy against colorectal cancer
Zhenhao Li, Jiaqiang Jiang, Yuping Zhou, Xinyuan Mao, Haotian Wen, Zhian Chen, Yutong Wang, Cong Huang, Yanfeng Hu   +8 more
wiley   +1 more source

Effect Size Estimation and Misclassification Rate Based Variable Selection in Linear Discriminant Analysis [PDF]

, 2012
Supervised classifying of biological samples based on genetic information, (e.g. gene expression profiles) is an important problem in biostatistics. In order to find both accurate and interpretable classification rules variable selection is indispensable.
Klaus, Bernd
core   +1 more source

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

Leveraging Linear Discriminant Analysis for Early Mental Health Disorder Identification

JRST: Jurnal Riset Sains dan Teknologi
Mental health disorders pose a significant global challenge, with early identification playing a crucial role in effective intervention and treatment.
Deden Iwan Setiawan, Marselina Endah Hiswati, Sriwidodo Sriwidodo, Mohammad Diqi, Luh Putu Erikawati, Rahayu Cahya Ariani   +5 more
doaj   +1 more source

Classification efficiencies for robust linear discriminant analysis. [PDF]

Linear discriminant analysis is typically carried out using Fisher’s method. This method relies on the sample averages and covariance matrices computed from the different groups constituting the training sample.
Croux, Christophe, Filzmoser, P., Joossens, Kristel   +2 more
core