Results 71 to 80 of about 282,422 (272)

Linear discriminant analysis of spatial Gaussian data with estimated anisotropy ratio

Lietuvos Matematikos Rinkinys, 2011
The paper deals with a problem of classification of Gaussian spatial data into one of two populations specified by different parametric mean models and common geometric anisotropic covariance function.
Lina Dreižienė
doaj   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

A Complete Subspace Analysis of Linear Discriminant Analysis and Its Robust Implementation

Journal of Electrical and Computer Engineering, 2016
Linear discriminant analysis has been widely studied in data mining and pattern recognition. However, when performing the eigen-decomposition on the matrix pair (within-class scatter matrix and between-class scatter matrix) in some cases, one can find ...
Zhicheng Lu, Zhizheng Liang
doaj   +1 more source

Saisir l’« Europe » à la lueur du discours officiel de l’UE : l’analyse de données au service d’une régionalisation critique de l’Europe

Belgeo, 2020
How to make the difference between a “European” state and a “non-European” state? This question is at the heart of the EU’s political project, which has already decided on this point to assess the candidacy of potential new members (case of Morocco in ...
Etienne Toureille
doaj   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Methylation Linear Discriminant Analysis (MLDA) for identifying differentially methylated CpG islands

BMC Bioinformatics, 2008
Background Hypermethylation of promoter CpG islands is strongly correlated to transcriptional gene silencing and epigenetic maintenance of the silenced state. As well as its role in tumor development, CpG island methylation contributes to the acquisition
Vass J Keith, Yan Pearlly, Huang Tim HM, Zeller Constanze, Graham Janet, Teodoridis Jens M, Dai Wei, Brown Robert, Paul Jim   +8 more
doaj   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

PENGENALAN WAJAH MENGGUNAKAN METODE LINEAR DISCRIMINANT ANALYSIS DAN K NEAREST NEIGHBOR

Jurnal Informatika, 2017
Pengenalan wajah merupakan sistem biometrika yang banyak digunakan untuk pengenalan individu pada penggunaan mesin absensi atau akses kontrol. Hal ini karena wajah merupakan salah satu ciri biometrika yang paling umum digunakan untuk mengenali seseorang.
Fandiansyah Fandiansyah, Jayanti Yusmah Sari, Ika Purwanti Ningrum   +2 more
doaj   +1 more source

A Bioinspired Three‐Dimensional High‐Curvature Nano‐Interface Integrated Microfluidic Chip for Small Extracellular Vesicles Enrichment and Machine Learning‐Assisted Prostate Cancer Precision Diagnosis

Advanced Science, EarlyView.
A biotin‐modified artificial insertion peptide functionalized three‐dimensional high‐curvature‐TiO2 nano‐interface was engineered in a microfluidic chip to improve the isolation efficiency of small extracellular vesicles (sEVs). This chip balanced affinity, releasability, and extendibility, enabling high‐throughput recovery of sEVs for downstream ...
Le Wang, Yizhong Liang, Manan Sulaiman, Jiaqi Du, Ming Jiang, Zhihua Wang, Xu Yu, Li Xu   +7 more
wiley   +1 more source