Results 71 to 80 of about 1,506,457 (286)

Pemt Inhibition‐Mediated Vdac1 Oligomerization Regulates Mitochondrial Dysfunction, Apoptosis, and Inflammation in High‐Fat Diet‐Derived Liver Injury

Advanced Science, EarlyView.
ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu, Xiufei Cao, Xin Yao, Baolin Li, Wencong Lai, Zengqi Zhao, Tingting Hao, Zhiwei Chen, Jianlong Du, Yueru Li, Kangsen Mai, Qinghui Ai   +11 more
wiley   +1 more source

A Complete Subspace Analysis of Linear Discriminant Analysis and Its Robust Implementation

Journal of Electrical and Computer Engineering, 2016
Linear discriminant analysis has been widely studied in data mining and pattern recognition. However, when performing the eigen-decomposition on the matrix pair (within-class scatter matrix and between-class scatter matrix) in some cases, one can find ...
Zhicheng Lu, Zhizheng Liang
doaj   +1 more source

Saisir l’« Europe » à la lueur du discours officiel de l’UE : l’analyse de données au service d’une régionalisation critique de l’Europe

Belgeo, 2020
How to make the difference between a “European” state and a “non-European” state? This question is at the heart of the EU’s political project, which has already decided on this point to assess the candidacy of potential new members (case of Morocco in ...
Etienne Toureille
doaj   +1 more source

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

Advanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu, Jiarong Yang, Miaoxuan Zhang, Yi Li, Zhuling Tu, Ji Wang, Jin‐Tai Yu, Kun Guo, Rongcan Luo   +8 more
wiley   +1 more source

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

Advanced Science, EarlyView.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen, Jiayi Liang, Yujia Wu, Jianan Xu, Yi Liu, Wenguang Wang, Xinhang Jiang, Benjie Gao, Yueyue Wang, Hui Jiang   +9 more
wiley   +1 more source

Methylation Linear Discriminant Analysis (MLDA) for identifying differentially methylated CpG islands

BMC Bioinformatics, 2008
Background Hypermethylation of promoter CpG islands is strongly correlated to transcriptional gene silencing and epigenetic maintenance of the silenced state. As well as its role in tumor development, CpG island methylation contributes to the acquisition
Vass J Keith, Yan Pearlly, Huang Tim HM, Zeller Constanze, Graham Janet, Teodoridis Jens M, Dai Wei, Brown Robert, Paul Jim   +8 more
doaj   +1 more source

Harmonic Mean Linear Discriminant Analysis

IEEE Transactions on Knowledge and Data Engineering, 2019
In machine learning and data mining, dimensionality reduction is one of the main tasks. Linear Discriminant Analysis (LDA) is a widely used supervised dimensionality reduction algorithm and it has attracted a lot of research interests.
Shuai Zheng, C. Ding, F. Nie, Heng Huang
semanticscholar   +1 more source

Brain‐Computer Interface Training Fosters Perceptual Skills to Detect Errors

Advanced Science, EarlyView.
Accurate perception of visuomotor errors underpins motor precision and learning, yet conventional behavioral training fails to improve sensitivity to subtle errors. Real‐time EEG‐based brain‐computer interface feedback targeting the error positivity component enhances perceptual learning of small errors.
Deland H. Liu, Fumiaki Iwane, Minsu Zhang, Leonardo G. Cohen, José del R. Millán   +4 more
wiley   +1 more source

PENGENALAN WAJAH MENGGUNAKAN METODE LINEAR DISCRIMINANT ANALYSIS DAN K NEAREST NEIGHBOR

Jurnal Informatika, 2017
Pengenalan wajah merupakan sistem biometrika yang banyak digunakan untuk pengenalan individu pada penggunaan mesin absensi atau akses kontrol. Hal ini karena wajah merupakan salah satu ciri biometrika yang paling umum digunakan untuk mengenali seseorang.
Fandiansyah Fandiansyah, Jayanti Yusmah Sari, Ika Purwanti Ningrum   +2 more
doaj   +1 more source

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

Advanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li, Zengnan Wu, Yingrui Zhang, Shulang Chen, Yongning Lin, Shiyu Chen, Tong Xu, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +9 more
wiley   +1 more source