Results 201 to 210 of about 701,348 (263)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Ultrafast photocurrent detection contradicts optical detection conclusions: Exciton diffusion contributes little to carbon nanotube device efficiency. [PDF]

Sci Adv
Faitz ZM, Blackwell CJ, Im D, Dhavamani A, Shen X, Arnold MS, Zanni MT.   +6 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Representations of Nonlocal Syntactic Dependencies Feed Verb Learning in Infancy. [PDF]

Dev Sci
Perkins L, Ying Y, Williams A, Lidz J.
europepmc   +1 more source

Optimization of Spent Coffee Grounds as Fat and Flour Substitutes in Gluten-Free Cakes: Effects on Quality Characteristics. [PDF]

Food Sci Nutr
Tiryaki G, Nakilcioğlu E.
europepmc   +1 more source

Do implant angulation and print orientation compromise masked stereolithography apparatus printer model accuracy? an in-vitro study. [PDF]

BMC Oral Health
Polat B, Ezmek B.
europepmc   +1 more source

Association between perfluoroalkyl and polyfluoroalkyl substances and response to the COVID-19 vaccine in a paediatric prospective observational cohort in Arizona. [PDF]

BMJ Paediatr Open
Hollister J, Porter C, Xiang B, Beitel SC, Rivers P, Lutrick K, Burgess JL, Ellingson KD.   +7 more
europepmc   +1 more source

Nonlinear viscoelastic models improve characterisation of 6 DOF intervertebral disc load response at low strain rates. [PDF]

Proc Inst Mech Eng H
Hayward S, Keogh PS, Miles AW, Gheduzzi S.   +3 more
europepmc   +1 more source

Quantitative Electroanalysis in Ionic Liquids Using Scanning Electrochemical Cell Microscopy. [PDF]

Anal Chem
Salek S, Byers JC.
europepmc   +1 more source