Results 101 to 110 of about 7,373 (275)
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo +7 more
wiley +1 more source
Linear forms in Logarithms and Diophantine equation
, 2022 The field of transcendance has a variety of subfields including : the transcendence of individual numbers, algebraic independence, transcendence of functions ( for example, modular forms, the zeta and $j$ functions, etc. ) at particular values, and applications to Diophantine equations which involve the linearly recurrent sequences (for example ...
openaire +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Primjena linearnih formi u logaritmima na rješavanje diofantskih jednadžbi [PDF]
, 2018 U ovom diplomskom radu, bavimo se primjenom linearnih formi u logaritmima na rješavanje diofantskih problema. Na početku rada iskazujemo osnovne pojmove i definicije koje su nam potrebne u nastavku rada.
Ilić, Marina
core
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
Binary BBP-Formulae for Logarithms and Generalized Gaussian-Mersenne Primes [PDF]
, 2003 Constants of the form where p and q are integer polynomials, deg p < deg q, and p(k)=q(k) is non-singular for nonnegative k and b 2, have special properties.
Marc Chamberland
core
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline
FEBS Open Bio, EarlyView.Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey +4 more
wiley +1 more source
A sharpening of the bounds for linear forms in logarithms [PDF]
Acta Arithmetica, 1972 openaire +2 more sources