Results 91 to 100 of about 20,855,140 (305)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

The Perron Condition for Delayed Systems with Caputo Fractional Derivatives

open access: yesMathematics
In the present work, we study a class of nonhomogeneous linear systems with fractional derivatives in Caputo’s sense of incommensurate order and distributed delays, satisfying the Perron condition.
Hristo Kiskinov   +3 more
doaj   +1 more source

An exact method for a discrete multiobjective linear fractional optimization [PDF]

open access: yes
Integer linear fractional programming problem with multiple objective MOILFP is an important field of research and has not received as much attention as did multiple objective linear fractional programming.
Chergui, M. E-A, Moulai, M.
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

Dynamics, Chaos Control, and Synchronization in a Fractional-Order Samardzija-Greller Population System with Order Lying in (0, 2)

open access: yesComplexity, 2018
This paper demonstrates dynamics, chaos control, and synchronization in Samardzija-Greller population model with fractional order between zero and two. The fractional-order case is shown to exhibit rich variety of nonlinear dynamics.
A. Al-khedhairi   +4 more
doaj   +1 more source

Iterative methods for solving fractional differential equations using non-polynomial splines [PDF]

open access: yesE-Journal of Analysis and Applied Mathematics
In this work, a non-polynomial spline function is proposed to solve a linear fractional differential equation where the derivatives are in the Caputo sense.
Faraidun K. Hamasalh   +2 more
doaj   +1 more source

Finite-Approximate Controllability of ν-Caputo Fractional Systems

open access: yes, 2023
This paper introduces a methodology for examining finite-approximate controllability in Hilbert spaces for linear/semilinear ν-Caputo fractional evolution equations.
Jihan Alahmadi   +5 more
core   +1 more source

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