Results 51 to 60 of about 136,748 (262)

Complexation of trivalent lanthanide cations with amino(O-alkyl)methylenephosphonic acids as the closest organophosphorus analogues of nitrilotriacetic acid

Учёные записки Казанского университета: Серия Естественные науки
The complexation of new complexones, analogues of nitrilotriacetic (H3NTA) and nitrilotrimethylenephosphonic (H6NTP) acids containing monobasic (O-alkyl)methylenephosphonic fragments as donor groups, with trivalent cations of lanthanides was studied. The
A. R. Garifzyanov, I. I. Mirzayanov, I. D. Shurygin, E. O. Chibirev, F. V. Devyatov   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Breaking linear scaling relationships in oxygen evolution via dynamic structural regulation of active sites

Nature Communications
The universal linear scaling relationships between the adsorption energies of reactive intermediates limit the performance of catalysts in multi-step catalytic reactions.
Zheye Zhang, Hongyan Zhao, Shibo Xi, Xiaoxu Zhao, Xiao Chi, Hong Bin Yang, Zhongxin Chen, Xiaojiang Yu, Yang-Gang Wang, Bin Liu, Peng Chen   +10 more
doaj   +1 more source

Predicting energy expenditures for activities of caribou from heart rates

Rangifer, 1986
Highly significant ...
Steve G. Fancy, Robert G. White
doaj   +1 more source

Large-Amplitude Vibrations of Spider Web Structures

Applied Sciences, 2020
Spider silk, as a natural material, shows exceptional performance in its properties. The combination of the superior properties of spider silk and the geometry of spider structures make the spider web very resilient.
Sakdirat Kaewunruen, Chayut Ngamkhanong, Tianyu Yang   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Desviaciones al modelo logarítmico-lineal en la solubilidad de ibuprofén y naproxén en mezclas cosolventes propilenoglicol-agua Deviations from log-linear solubility equation for ibuprofen and naproxen in propylene glycol-water cosolvent mixtures

Química Nova, 2007
The deviations observed in the solubility of ibuprofen (IBP) and naproxen (NAP) in propylene glycol (PG) + water (W) cosolvent mixtures with respect to the logarithmic-linear model proposed by Yalkowsky have been analyzed at 25.00 ± 0.05 ºC ...
Edgar F. Vargas, Yady J. Manrique, Diana P. Pacheco, Norma S. Torres, Fleming Martínez   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source