Results 211 to 220 of about 143,351 (265)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Reconstruction of Multiplex Networks with Correlated Layers. [PDF]

Entropy (Basel)
Gemmetto V, Garlaschelli D.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Association Between Upper Extremity Function and Independence in Activities of Daily Living in Individuals with Motor-Incomplete Tetraplegia: An Exploratory Cross-Sectional Study. [PDF]

J Funct Morphol Kinesiol
Strongylou E, Karadimitri D, Moutzouri M, Stamou M, Rapidi CA, Dionyssiotis Y, Moumtzi-Nakka E, Sakellari V.   +7 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Impact of a Dedicated Trauma Consult Service on Burnout Among Physicians and Nurses: A Longitudinal Survey. [PDF]

Cureus
Green R, Green D, Harris A, Gillis B, Sturge S, Cashen D, Ferguson H, Opra I.   +7 more
europepmc   +1 more source

Correcting for a Baseline Difference in Group Comparisons on a Binary Outcome: Covariate Adjustment or Analysis of Change? [PDF]

Stat Med
Van Breukelen GJP.
europepmc   +1 more source

Prediction of Stroke Outcomes in a Super-aged Society: Different Effects Among Predictive Variables. [PDF]

Cureus
Kanata Y, Uchiyama Y, Matsushima S, Kanatani M, Koyama T, Domen K.   +5 more
europepmc   +1 more source

Agitation Severity and Psychotropic Prescription in Acute Patients With Delirium Superimposed on Dementia. [PDF]

Psychogeriatrics
Falciola J, Herrmann FR, Graf CE, Mendes A.   +3 more
europepmc   +1 more source

The impact of El Niño-Southern Oscillation on the incidence of infectious diarrhea in China: insights from a 15-year national surveillance analysis. [PDF]

Front Public Health
Ou K, Li X, Zeng W, Shi Y, Rong Z, Zhang Y, Xiao S, Fan Z, Geng M, Tu H, Xiao J.   +10 more
europepmc   +1 more source