Results 101 to 110 of about 24,946,429 (302)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Linear mixed effects model of matching judgments.
, 2019 Linear mixed effects model of matching judgments.
Tyler Surber (6256108) +4 more
core +1 more source
Altitude-dependent accumulation of gentiopicroside in Gentiana rigescens
HeliyonMany terpenoids are synthesized by specific plant taxa in response to particular ecological situations. Gentiopicroside is a secoiridoid glycoside belonging to the broader class of iridoid-derived monoterpenoids, and occurs mainly in plants of the genus ...
Yingmei Zuo +3 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Smoothing with Mixed Model Software [PDF]
Smoothing methods that use basis functions with penalization can be formulated as fits in a mixed model framework. One of the major benefits is that software for mixed model analysis can be used for smoothing.
Matthew P. Wand, Long Ngo
core
Exploration latency—Restricted Linear Mixed effects Model.
, 2016 Exploration latency—Restricted Linear Mixed effects Model.
Jan-Åke Nilsson (68493) +2 more
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Exploration latency—Full Linear Mixed effects Model.
, 2016 Exploration latency—Full Linear Mixed effects Model.
Jan-Åke Nilsson (68493) +2 more
core +1 more source
TechnologiesThe spontaneous oscillations within the brain are intimately linked to the hierarchical structures of the cortex, as evidenced by the cross-cortical gradient between parametrized spontaneous oscillations and cortical locations.
Xiaoyu Liang +7 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source