The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
The R Package metaLik for Likelihood Inference in Meta-Analysis
Journal of Statistical Software, 2012 Meta-analysis is a statistical method for combining information from different studies about the same issue of interest. Meta-analysis is widely diffuse in medical investigation and more recently it received a growing interest also in social disciplines.
Annamaria Guolo, Cristiano Varin
doaj
Mechanisms associated with the trajectory of depressive and anxiety symptoms: A linear mixed-effects model during the COVID-19 Pandemic. [PDF]
Curr Psychol, 2022 Ebrahimi OV, Hoffart A, Johnson SU.
europepmc +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Assessing Opioid Use Disorder Treatments in Trials Subject to Non-Adherence via a Functional Generalized Linear Mixed-Effects Model. [PDF]
Int J Environ Res Public Health, 2022 St Ville M +4 more
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Trend-resistant and cost-efficient cross-over designs for mixed models. [PDF]
A mixed model approach is used to construct optimal cross-over designs. In a cross-over experiment the same subject is tested at different points in time.
Tack, L, Vandebroek, Martina
core
Definition of a linear equivalent model for a non-linear system with impacts [PDF]
, 2012 Modal characteristics of non-linear system are typically studied through response to harmonic excitation and using various definitions of non-linear modes. However, few results are available for systems under broadband excitation.
BALMES, Etienne +2 more
core
Spatial distribution of traditional male circumcision and associated factors in Ethiopia; using multilevel generalized linear mixed effects model. [PDF]
BMC Public Health, 2021 Tusa BS +3 more
europepmc +1 more source