Results 131 to 140 of about 18,112,323 (302)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

R Package wgaim: QTL Analysis in Bi-Parental Populations Using Linear Mixed Models [PDF]

The wgaim (whole genome average interval mapping) package developed in the R system for statistical computing (R Development Core Team 2011) builds on linear mixed modelling techniques by incorporating a whole genome approach to detecting significant ...
Julian Taylor, Arunas Verbyla
core  

Mixed model based inference in structured additive regression [PDF]

, 2006
Due to the increasing availability of spatial or spatio-temporal regression data, models that allow to incorporate the special structure of such data sets in an appropriate way are highly desired in practice.
Kneib, Thomas
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Mixed Linear Model Approaches for Quantitative Gen

, 2019
Purpose Computer software for estimating variance and covariance components, correlations, and predicting genetic effects. Software Description We describe a suite of genetic software that employs mixed linear model approaches.
Junmei Zhu (17480904), Jixiang Wu (10348019), Johnie N. Jenkins (17480907)   +2 more
core  

Applying Linear Mixed Effects Models with Crossed Random Effects to Psycholinguistic Data: Multilevel Specification and Model Selection. [PDF]

Tutorials in Quantitative Methods for Psychology, 2015
Applying linear mixed effects regression (LMER) models to psycholinguistic data was made popular by Baayen, Davidson, and Bates (2008). However, applied researchers sometimes encounter model specification difficulties when using such models.
Hsiu-Ting Yu
doaj  

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

A Simple GMM Estimator for the Semi-Parametric Mixed Proportional Hazard Model [PDF]

Ridder and Woutersen (2003) have shown that under a weak condition on the baseline hazard there exist root-N consistent estimators of the parameters in a semiparametric Mixed Proportional Hazard model with a parametric baseline hazard and unspecified ...
Ridder, Geert, Bijwaard, Govert
core