Results 141 to 150 of about 2,452,838 (337)

Sparse Estimation Strategies in Linear Mixed Effect Models for High-Dimensional Data Application [PDF]

, 2021
Eugene A. Opoku, S. Ejaz Ahmed, Farouk S. Nathoo   +2 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Bayesian linear mixed model with multiple random effects for family-based genetic studies. [PDF]

Front Genet, 2023
Hai Y, Zhao W, Meng Q, Liu L, Wen Y.
europepmc   +1 more source

A Novel Linear B-spline Mixed Model for Repeated Measures (LB-MMRM) for Alzheimer’s Disease Clinical Study Data [PDF]

Kun Jin, William R Chezem, Guoqiao Wang
openalex   +1 more source

Mixing Frequencies : Stock Returns as a Predictor of Real Output Growth [PDF]

We investigate two methods for using daily stock returns to forecast, and update forecasts of, quarterly real output growth. Both methods aggregate daily returns in some manner to form a single stock market variable.
Anthony S. Tay
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The Relation between Hearing Loss and Smoking among Workers Exposed to Noise, Using Linear Mixed Models.

, 2020
Fatemeh Khaldari, Narges Khanjani, Abbas Bahrampour, Mohammad Reza Ghotbi Ravandi, Ali Asghar Arabi Mianroodi   +4 more
openalex   +2 more sources

Measuring connectedness among herds in mixed linear models: From theory to practice in large-sized genetic evaluations [PDF]

, 2008
Marie-Noëlle Fouilloux, Virginie Clément, Dénis Laloë   +2 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Study on Bayesian Skew-Normal Linear Mixed Model and Its Application in Fire Insurance. [PDF]

Fire Technol, 2023
Gong M, Mao Z, Zhang D, Ren J, Zuo S.
europepmc   +1 more source