Results 201 to 210 of about 2,452,838 (337)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Risk factors for non-communicable diseases among Bangladeshi adults: an application of generalised linear mixed model on multilevel demographic and health survey data. [PDF]

BMJ Open
Nahin KSA, Jannatul T.
europepmc   +1 more source

The handling of missing data in trial-based economic evaluations: should data be multiply imputed prior to longitudinal linear mixed-model analyses? [PDF]

Eur J Health Econ, 2023
Ben ÂJ, van Dongen JM, Alili ME, Heymans MW, Twisk JWR, MacNeil-Vroomen JL, de Wit M, van Dijk SEM, Oosterhuis T, Bosmans JE.   +9 more
europepmc   +1 more source

A penta-dimensional longitudinal analysis of the predictors of compulsive internet use among adolescents using linear mixed model (LMM)

, 2012
Xiaolong Li
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Prediction of Junior High School Students’ Problematic Internet Use: The Comparison of Neural Network Models and Linear Mixed Models in Longitudinal Study

Psychology Research and Behavior Management
Mei Tian,1 Qiulian Xing,2 Xiao Wang,2 Xiqing Yuan,2 Xinyu Cheng,2 Yu Ming,2 Kexin Yin,2 Zhi Li,2 Peng Wang2 1Library, Shandong Normal University, Jinan, People’s Republic of China; 2School of Psychology, Shandong Normal University, Jinan, People’s ...
Tian M, Xing Q, Wang X, Yuan X, Cheng X, Ming Y, Yin K, Li Z, Wang P   +8 more
doaj  

When a joint model should be preferred over a linear mixed model for analysis of longitudinal health-related quality of life data in cancer clinical trials. [PDF]

BMC Med Res Methodol, 2023
Touraine C, Cuer B, Conroy T, Juzyna B, Gourgou S, Mollevi C.   +5 more
europepmc   +1 more source

On modeling the single period spare parts distribution system design problem by mixed integer linear optimization [PDF]

, 2019
Hazal Ercan
openalex  

Ultrasonographic determination of day of parturition based on fetal biparietal diameter in pregnant bitches: Comparison of simple linear regression and mixed linear regression in breed-specific models and maternal weight grouped models

, 2022
Monica Due Pedersen, Anja Bach Klesiewicz, Henriette Medom Marqvorsen, Hanne Gervi Pedersen, Jan Bojsen‐Møller Secher   +4 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source