Results 201 to 210 of about 3,822,020 (321)

msqrob2TMT: Robust Linear Mixed Models for Inferring Differential Abundant Proteins in Labeled Experiments With Arbitrarily Complex Design. [PDF]

Mol Cell Proteomics
Vandenbulcke S, Vanderaa C, Crook O, Martens L, Clement L.   +4 more
europepmc   +1 more source

Analyzing dynamic species abundance distributions using generalized linear mixed models. [PDF]

Ecology, 2022
Solbu EB, van der Veen B, Herfindal I, Hovstad KA.   +3 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Matrix sketching framework for linear mixed models in association studies. [PDF]

Genome Res
Burch M, Bose A, Dexter G, Parida L, Drineas P.   +4 more
europepmc   +1 more source

Efficient penalized generalized linear mixed models for variable selection and genetic risk prediction in high-dimensional data. [PDF]

Bioinformatics, 2023
St-Pierre J, Oualkacha K, Bhatnagar SR.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The R2D2 prior for generalized linear mixed models. [PDF]

Am Stat
Yanchenko E, Bondell HD, Reich BJ.
europepmc   +1 more source

Trade-offs of Linear Mixed Models in Genome-Wide Association Studies. [PDF]

J Comput Biol, 2022
Wang H, Aragam B, Xing EP.
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

LiMMCov: An interactive research tool for efficiently selecting covariance structures in linear mixed models using insights from time series analysis. [PDF]

PLoS One
Savieri P, Stas L, Barbé K.
europepmc   +1 more source