Results 251 to 260 of about 2,001,852 (330)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Time course of log IL-6 over time among the L, I and H phenotypes. Values are means plus/minus standard deviations. Negative values are possible because they are predicted values. For each phenotype, 5 time points were considered (D1, D7, D14, D21, D28). Linear mixed model, p=0.175.

open access: green
Nicolas Partouche (17777862)   +9 more
openalex   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Anxiety and depression sub-scale scores from the 10-item Kessler Psychological Distress Scale for Ontario education workers participating in the COVID-19 Cohort Study, February 18, 2021 to December 22, 2023, estimates using linear mixed effects models.

open access: green
Iris Gutmanis (19454389)   +7 more
openalex   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

The standardized coefficients (mean ±  95% confidence interval) of Linear Mixed Models for fish ecological indicators calculated for protected (MUMPA: blue) and non-protected (NP: orange) sites of the Oaxaca coast are presented.

open access: green
Georgina Ramírez-Ortiz (21484870)   +4 more
openalex   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

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