Results 121 to 130 of about 12,380,363 (249)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
On Some Analogues to Linear Combinations of Order Statistics in the Linear Model
The Annals of Statistics, 1973 We consider the general linear model with independent symmetric errors. In this context we propose and examine the large sample behavior of some estimates of the regression parameters. For the location model these statistics are linear combinations of order statistics.
openaire +3 more sources
A survey on generalized linear models (GLMS) and their diagnostic tools
, 2017 An important statistical development in the last four decades has been the advancement in the field of regression analysis for a variety of response variables under the umbrella of an exponential family of distributions.
Alsidrani, Fahad Abdulaziz
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Nonparametric checks for count data models: an application to demand for health care in Spain [PDF]
, 1997 This paper presents model specification checking procedures for count data regression models which are consistent in the direction of nonparametric alternatives.
Delgado, Miguel A., Álvarez, Begoña
core
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
GLiM: Generalized linear models
, 2017 Much was written on generalized linear models. The reader is referred to the following books: P. McCullagh and J. A. Nelder, Generalized Linear Models, 2nd edn. (Chapman & Hall, 1989); A. J. Dobson and A.
Joseph R. Barr, Shelemyahu Zacks
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source