Results 121 to 130 of about 11,029,261 (299)
Estimation in Partially Linear Single-Index Panel Data Models with Fixed Effects [PDF]
In this paper, we consider semiparametric estimation in a partially linear single-index panel data model with fixed effects. Without taking the difference explicitly, we propose using a semiparametric minimum average variance estimation (SMAVE) based on ...
Jia Chen, Jiti Gao, Degui Li
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Hierarchical Generalized Linear Models: The R Package HGLMMM [PDF]
The R package HGLMMM has been developed to fit generalized linear models with random effects using the h-likelihood approach. The response variable is allowed to follow a binomial, Poisson, Gaussian or gamma distribution.
Marek Molas, Emmanuel Lesaffre
core
On Some Analogues to Linear Combinations of Order Statistics in the Linear Model
The Annals of Statistics, 1973 We consider the general linear model with independent symmetric errors. In this context we propose and examine the large sample behavior of some estimates of the regression parameters. For the location model these statistics are linear combinations of order statistics.
openaire +3 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Business use of information technology statistics 2013-14
, 2015 This release includes information of business use of cloud computing for the first time, as well as internet access, social media presence and internet commerce.
Australian Bureau of Statistics
core
Testing structural change in partially linear single-index models with error-prone linear covariates
, 2012 Motivated by an analysis of a real data set from Duchenne Muscular Dystrophy (Andrews and Herzberg, 1985), we propose a new test of structural change for a class of partially linear single-index models with error-prone linear covariates.
Huang, Zhensheng, Pang, Zhen, Hu, Tao
core +1 more source