Results 111 to 120 of about 11,029,261 (299)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Error bounds for the convex loss Lasso in linear models
, 2017 In this paper we investigate error bounds for convex loss functions for the Lasso in linear models, by first establishing a gap in the theory with respect to the existing error bounds.
Deléamont, Pierre-Yves +3 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Bayes Linear Variance Learning for Mixed Linear Temporal Models [PDF]
, 2012 Modelling of complex corroding industrial systems is ritical to effective inspection and maintenance for ssurance of system integrity. Wall thickness and corrosion rate are modelled for multiple dependent corroding omponents, given observations of ...
RANDELL, DAVID
core
Detection theory as application to the radar with a self-oscillating feedback
Известия высших учебных заведений России: Радиоэлектроника, 2015 The physical and mathematical models of radar with feedback through space and target, operating on the principle of self-oscillating system are discussed. The linear mode of fluctuations establishing is analyzed.
V. M. Kutuzov, V. N. Popov
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Order statistics under linear trend
, 1991 Order statistics and linear functions of order statistics are frequently used as estimators of location and scale. The moments of order statistics have been tabled for many commonly used distributions under assumptions of independence and identical ...
Robison-Cox, James
core +1 more source
Assessing identification risk in survey microdata using log-linear models
, 2006 This article considers the assessment of the risk of identification of respondents in survey microdata, in the context of applications at the United Kingdom (UK) Office for National Statistics (ONS). The threat comes from the matching of categorical 'key'
Shlomo, Natalie, Skinner, Chris
core +1 more source
ON SOME STATISTICAL MODELS FOR ASSESSING THE EVOLUTION OF SALES OF CERTAIN PRODUCTS [PDF]
Annals of the University of Petrosani: Economics, 2016 The mathematical statistic models are very used in solving of many types of engineering, economic and other practical issues. This paper aims to analyse the evolution of the prices of a particular type of a product for one year.
CĂTĂLIN ILIE MITRAN
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source