Results 91 to 100 of about 2,137,261 (292)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Focused information criterion and model averaging for generalized additive partial linear models
, 2011 We study model selection and model averaging in generalized additive partial linear models (GAPLMs). Polynomial spline is used to approximate nonparametric functions.
Liang, Hua, Zhang, Xinyu
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
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Delete or merge regressors for linear model selection
, 2015 We consider a problem of linear model selection in the presence of both continuous and categorical predictors. Feasible models consist of subsets of numerical variables and partitions of levels of factors.
Maj-Kańska, Aleksandra +2 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
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Linear statistical models in psychology
, 2021 Different kinds of linear regressions are useful in solving a wide range of problems encountered in psychology and other areas of empirical research. Procedures belonging to this family find their application in the processing of experimental data, in the analysis of questionnaire surveys and, for example, in the development of test norms. This text is
openaire +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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Comparing non-linear mathematical models to describe growth of different animals
Acta Scientiarum: Animal Sciences, 2017 The main objective of this study was to compare the goodness of fit of five non-linear growth models, i.e. Brody, Gompertz, Logistic, Richards and von Bertalanffy in different animals. It also aimed to evaluate the influence of the shape parameter on the
Jhony Tiago Teleken +2 more
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, 2014 This paper derives central limit theorems (CLTs) for general linear spectral statistics (LSS) of three important multi-spiked Hermitian random matrix ensembles.
Chen, Yang +2 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
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