Results 191 to 200 of about 283,344 (265)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Delayed transcallosal conduction to the lesioned sensorimotor cortex in multiple Sclerosis: A combined TMS 7 T-MRI study. [PDF]

Neuroimage Clin
Madsen MAJ, Christiansen L, Wiggermann V, Lundell H, Christensen JR, Blinkenberg M, Sellebjerg F, Siebner HR.   +7 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Structural brain lesions and action observation therapy outcomes in unilateral cerebral palsy: an exploratory study. [PDF]

Front Syst Neurosci
Cruz-Sanabria F, Beani E, Menici V, Filogna S, Bosco P, Fiori S, Biagi L, Sgandurra G.   +7 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Commentary: The influence of linear and nonlinear pedagogy on motor skill performance: the moderating role of adaptability. [PDF]

Front Psychol
Praça GM, Abebe Y, De Oliveira Santos Silva G, Figueiredo LS, Diniz S, Aburachid LMC.   +5 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Handgrip weakness is associated with motor cortex atrophy in rheumatoid arthritis: a cross-sectional study with a hand exercise intervention. [PDF]

BMC Med
Gustafsson AL, Heckemann RA, Erlandsson MC, Lundgren VM, Dai Z, Silfverswärd ST, Pullerits R, Bokarewa MI, Wasén C.   +8 more
europepmc   +1 more source

Keeping it together: Hourly dynamics of children's behavioral regulation at school in a decades-long cohort study. [PDF]

Dev Psychol
Koepp AE, Gershoff ET, Vandell DL, Duckworth AL, Mackey AP.   +4 more
europepmc   +1 more source