Results 101 to 110 of about 176,678 (310)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

On the conditional distribution of a multivariate Normal given a transformation – the linear case

Heliyon, 2019
We show that the orthogonal projection operator onto the range of the adjoint T⁎ of a linear operator T can be represented as UT, where U is an invertible linear operator. Given a Normal random vector Y and a linear operator T, we use this representation
Rajeshwari Majumdar, Suman Majumdar
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Estimation de la fréquence instantanée des signaux FM par opérateur d'énergie Psi_B [PDF]

, 2011
Psi_B energy operator is an extension of the cross Teager-Kaiser energy operator which is an non-linear energy tracking operator to deal with complex signals and its usefulness for non-stationary signals analysis has been demonstrated. In this letter two
BOUDRAA, Abdel-Ouahab
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Subordination preserving properties associated with a class of operators

Le Matematiche, 2013
The purpose of this paper is to find some subordination preserving properties of analytic functions associated with a class of operators with complex parameters.
Poonam Sharma, Ravinder K. Raina
doaj  

TWO METHODS OF DESCRIBING 2-LOCAL DERIVATIONS AND AUTOMORPHISMS

Ural Mathematical Journal
In the present paper, we investigate 2-local linear operators on vector spaces. Sufficient conditions are obtained for the linearity of a 2-local linear operator on a finite-dimensional vector space. To do this, families of matrices of a certain type are
Farhodjon Arzikulov, Feruza Nabijonova, Furkat Urinboyev   +2 more
doaj   +1 more source

A Voronovskaya-type theorem for a positive linear operator

International Journal of Mathematics and Mathematical Sciences, 2006
We consider a sequence of positive linear operators which approximates continuous functions having exponential growth at infinity.
Alexandra Ciupa
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source