Results 71 to 80 of about 5,164,048 (315)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

About a general property for a class of linear positive operators and applications

Journal of Numerical Analysis and Approximation Theory, 2005
In this paper we demonstrate a general property for a class of linear positive operators. By particularization, we obtain the convergence and the evaluation for the rate of convergence in term of the first modulus of smoothness for the Bernstein ...
Ovidiu T. Pop
doaj   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Linear positive operators generated by functions

Journal of Numerical Analysis and Approximation Theory, 1976
Not available.
G.A. Jägers
doaj   +2 more sources

DONKIN'S DIFFERENTIAL OPERATORS FOR HOMOGENEOUS HARMONIC FUNCTIONS

St. Petersburg Polytechnical University Journal: Physics and Mathematics, 2019
The work continues the study of Donkin operators for homogeneous harmonic functions. Previously, a basic list of such first-order operators for three-dimensional harmonic functions was obtained.
Berdnikov Alexander, Gall Lidia, Gall Nikolaj, Solovyev Konstantin   +3 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Neural Networks as Positive Linear Operators

Mathematics
Basic neural network operators are interpreted as positive linear operators and the related general theory applies to them. These operators are induced by a symmetrized density function deriving from the parametrized and deformed hyperbolic tangent ...
George A. Anastassiou
doaj   +1 more source

Continuous linear operators on Orlicz-Bochner spaces

Open Mathematics, 2019
Let (Ω, Σ, μ) be a complete σ-finite measure space, φ a Young function and X and Y be Banach spaces. Let Lφ(X) denote the corresponding Orlicz-Bochner space and Tφ∧$\begin{array}{} \displaystyle \mathcal T^\wedge_\varphi \end{array}$ denote the finest ...
Nowak Marian
doaj   +1 more source

C^mextension by linear operators [PDF]

, 2007
Charles Fefferman
openalex   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source