Results 41 to 50 of about 916 (191)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Aspects of electromagnetic scattering in chiral media [PDF]
, 2017 In this work, we study two operators that arise in electromagnetic scattering in chiral media. We first consider electromagnetic scattering by a chiral dielectric with a perfectly conducting core.
Kikeri, E. +3 more
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Applications of Degree Theories to Nonlinear Operator Equations in Banach Spaces [PDF]
, 2007 Let X be a real Banach space and G1, G2 two nonempty, open and bounded subsets of X such that 0 ∈ G2 and G2 ⊂ G1. The problem (∗) T x + Cx = 0 is considered, where T : X ⊃ D(T) → X is an accretive or monotone operator with 0 ∈ D(T) and T(0) = 0, while C :
Adhikari, Dhruba R
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Semilinear Problems and Spectral Theory [PDF]
, 1997 The subject of this thesis is that part of nonlinear functional analysis which deals with the solvability of semilinear differential equations and the study of spectral theory for nonlinear operators.
Feng, Wenying
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Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
, 1986 1986 / 1-2. szám Miccoli, Maria Maddalena: Bi-ideals in regular semigroups and in orthogroups Amin, I. A.: On a problem of Kaplansky Horváth L.: Strong approximations of renewal processes and their applications Sebestyén Z.: On ...
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