Results 51 to 60 of about 8,645,321 (278)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

On a generalization of the Stancu-Schurer operator of higher order

Journal of Numerical Analysis and Approximation Theory
In this paper, we introduce a generalization of the higher-order Stancu–Schurer operator. Starting from a particular form of the operator recently introduced by the authors, we extend the convex combination of two terms appearing in its expression to a ...
Eduard Stefan Grigoriciuc, Andra Malina
doaj   +3 more sources

Multivariate trigonometric Korovkin theorem within a fuzzy framework [PDF]

Mathematica Moravica
In this paper, the trigonometric fuzzy Korovkin theorem, originally established by G. A. Anastassiou and S. G. Gal (Nonlinear Functional Analysis and Applications, 11 (2006), 385-395), is extended to the k-dimensional setting. The proof is based on a new
Taş Emre, Ekici Selma
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Approximation Theorems for q- Analouge of a Linear Positive Operator by A. Lupas

International Journal of Analysis and Applications, 2016
The purpose of the present paper is to introduce $q-$ analouge of a sequence of linear and positive operators which was introduced by A. Lupas [2]. First, we estimate moments of the operators and then prove a basic convergence theorem.
Karunesh Kumar Singh, Asha Ram Gairola, Deepmala .   +2 more
doaj   +2 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Eigenvalue counting estimates for a class of linear spectral pencils with applications to zero modes [PDF]

, 2012
Consider a linear spectral pencil of the form P(−i∇)− zQ(x), z ∈ C. If P−1 ∈ weak-Lp and Q ∈ Lp for some 1 < p
Elton, Daniel, Ta, Tri Ngoc
core   +4 more sources

On a Family of Parameter-Based Bernstein Type Operators with Shape-Preserving Properties

Journal of Mathematics, 2023
This article aims to introduce a new linear positive operator with a parameter. Our focus lies in analyzing the distinct characteristics and inherent properties exhibited by this operator.
Bahareh Nouri, Jamshid Saeidian
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source