Results 51 to 60 of about 986,527 (283)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Weighted A-Statistical Convergence for Sequences of Positive Linear Operators

open access: yesThe Scientific World Journal, 2014
We introduce the notion of weighted A-statistical convergence of a sequence, where A represents the nonnegative regular matrix. We also prove the Korovkin approximation theorem by using the notion of weighted A-statistical convergence. Further, we give a
S. A. Mohiuddine   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Weakly Ordered A-Commutative Partial Groups of Linear Operators Densely Defined on Hilbert Space [PDF]

open access: yes, 2017
The notion of a generalized effect algebra is presented as a generalization of effect algebra for an algebraic description of the structure of the set of all positive linear operators densely defined on a Hilbert space with the usual sum of operators ...
Janda , Jirí
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Some properties of the linear positive operators (III)

open access: yesJournal of Numerical Analysis and Approximation Theory, 1974
Not available.
A. Lupaş
doaj   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Asymptotic Behaviour of the Iterates of Positive Linear Operators

open access: yesAbstract and Applied Analysis, 2011
We present a general result concerning the limit of the iterates of positive linear operators acting on continuous functions defined on a compact set.
Ioan Gavrea, Mircea Ivan
doaj   +1 more source

On the Monotonicity of Positive Linear Operators

open access: yesJournal of Approximation Theory, 1998
The main result of this paper concerns positive linear approximation operators of the so-called Feller type \[ K_n(f,x): =Ef(T_{n,x}) =\int_I f(t)dG_{n,x} (t),\;n\in\mathbb{N}, \] where the random variable \(T_{n,x}\) is the arithmetic mean of identically distributed random variables \(X_{i,x}\), \(I=1, \dots, n\) taking values in an interval \(I\) and
KHAN M. K.   +2 more
openaire   +3 more sources

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