Results 91 to 100 of about 10,981,728 (293)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Nonconvex and nonsmooth optimization for robust control and power systems [PDF]

, 2018
University of Technology Sydney. Faculty of Engineering and Information Technology.There is considerable interest in structured H∞ control in linear parameter varying (LPV) systems and Tagaki-Sugeno (T-S) fuzzy systems.
Shi, Ye
core  

Breaking the 200nm limit for routine flow linear dichroism measurements using UV synchrotron radiation [PDF]

, 2008
The first synchrotron radiation flow linear dichroism spectra are reported. High-quality spectral data can be collected from 450 nm down to 180 nm in contrast to the practical cutoff of not, vert, similar200 nm on benchtop instruments.
Hicks, MR, Rodger, A, Dicko, Cedric, Dicko, C, Hoffmann, SV, Rodger, Alison, Dafforn, Tim, Vollrath, Fritz, Hicks, Matthew R., Hoffmann, Søren V., Dafforn, Timothy, Vollrath, F   +11 more
core   +1 more source

Fully distributed AC power flow (ACPF) algorithm for distribution systems

IET Smart Grid, 2018
Power flow is one of the basic tools for system operation and control. Due to its nature, which determines the complex nodal voltages, line flows, currents and losses, it enforces a large computation load on a power system.
Hajir Pourbabak, Adetokunbo Ajao, Tao Chen, Wencong Su   +3 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Intelligent layout and location method of electric vehicle charging piles based on time series power flow calculation [PDF]

AIP Advances
To avoid the unreasonable layout and location of charging piles affecting the power flow state of a power system, an intelligent layout and location method for charging piles of electric vehicles based on time-series power flow calculation is proposed ...
Min Zhao, Guohui Li, Han Cheng
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Security constrained reactive power dispatch in electrical power systems [PDF]

, 1990
With the increased loading and exploitation of the power transmission system and also due to improved optimised operation, the problem of voltage stability and voltage collapse attracts more and more attention .
Chebbo, Ahmad Mustapha
core