Results 41 to 50 of about 64,350 (258)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A Computationally Efficient Method for the Diagnosis of Defects in Rolling Bearings Based on Linear Predictive Coding

Algorithms
Monitoring the condition of rolling bearings is a crucial task in many industries. An efficient tool for diagnosing bearing defects is necessary since they can lead to complete machine failure and significant economic losses.
Mohammad Mohammad, Olga Ibryaeva, Vladimir Sinitsin, Victoria Eremeeva   +3 more
doaj   +1 more source

Blood Volume Pulse Extraction for Non-Contact Heart Rate Measurement by Digital Camera Using Singular Value Decomposition and Burg Algorithm

Energies, 2018
Conventional photoplesthymograph (PPG) measurements for heart rate (HR) determination require direct contact between the patient and the PPG device sensor. When using the conventional method, it is possible for users to suffer undesirable skin irritation,
Iman Rahmansyah Tayibnapis, Yeon-Mo Yang, Ki Moo Lim   +2 more
doaj   +1 more source

Predictive Coding: A Possible Explanation of Filling-In at the Blind Spot. [PDF]

PLoS ONE, 2016
Filling-in at the blind spot is a perceptual phenomenon in which the visual system fills the informational void, which arises due to the absence of retinal input corresponding to the optic disc, with surrounding visual attributes. It is known that during
Rajani Raman, Sandip Sarkar
doaj   +1 more source

Comparison of Khasi speech representations with different spectral features and hidden Markov states

Journal of Electronic Science and Technology, 2021
In this paper, we present a comparison of the Khasi speech representations with four different spectral features and novel extension towards the development of Khasi speech corpora.
Bronson Syiem, Sushanta Kabir Dutta, Juwesh Binong, Lairenlakpam Joyprakash Singh   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Techniques for The Regeneration of Wideband Speech from Narrowband Speech

EURASIP Journal on Advances in Signal Processing, 2001
This paper addresses the problem of reconstructing wideband speech signals from observed narrowband speech signals. The goal of this work is to improve the perceived quality of speech signals which have been transmitted through narrowband channels or ...
Gardner William R, Fuemmeler Jason A, Hardie Russell C   +2 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source