Results 91 to 100 of about 16,945 (232)

Distinct effects of complement C4A and C4B copy number in Systemic Sclerosis serological and clinical subtypes

Arthritis &Rheumatology, Accepted Article.
Objective Complement component 4 (C4), encoded by C4A and C4B within the major histocompatibility complex (MHC) on chromosome 6, regulates the immune response and clears immune complexes. Variable copy number (CN) of C4 genes and retroviral HERV‐K element influence its function.
Javier Martínez‐López, Carlos Rangel‐Peláez, Inmaculada Rodriguez‐Martin, Alfredo Guillen‐Del‐Castillo, Carmen P Simeón‐Aznar, José L Callejas, International SSc Group; PRECISESADs Clinical Consortium, Oliver Distler, Susanna M Proudman, Mandana Nikpour, Australian Scleroderma Interest Group (ASIG), Nicolas Hunzelmann, Gianluca Moroncini, Jeska K de Vries‐Bouwstra, Ariane L Herrick, Yannick Allanore, Marta E. Alarcon‐Riquelme, Lorenzo Beretta, Shervin Assassi, Christopher P Denton, Maureen D Mayes, Javier Martin, Marialbert Acosta‐Herrera, Martin Kerick   +23 more
wiley   +1 more source

Parry-Romberg Syndrome Associated with Localized Scleroderma

Case Reports in Neurology, 2010
Parry-Romberg syndrome is a rare neurocutaneous disorder of unknown origin. It is characterized by progressive facial hemiatrophy and frequently overlaps with a condition known as linear scleroderma ‘en coup de sabre’.
Jelena Maletic, Vassiliki Tsirka, Panos Ioannides, Dimitrios Karacostas, Nikolaos Taskos   +4 more
doaj   +1 more source

DNA content of a functioning chicken kinetochore [PDF]

, 2014
© The Author(s) 2014. In order to understand the three-dimensional structure of the functional kinetochore in vertebrates, we require a complete list and stoichiometry for the protein components of the kinetochore, which can be provided by genetic and ...
A Alonso, AE Barry, AF Pluta, AP Joglekar, BA Sullivan, BR Brinkley, CM Wade, D Gerlich, D Sart du, D Varma, DR Foltz, FG Westhorpe, H Maiato, H Saitoh, IM Cheeseman, J Dekker, JH Hegemann, K Jaqaman, LL Sullivan, LS Burrack, MD Blower, N Naumova, O Capozzi, OJ Marshall, P Luykx, P Vagnarelli, Paola Vagnarelli, PT Jokelainen, R Saffery, SA Ribeiro, SA Ribeiro, Susana Abreu Ribeiro, T Fukagawa, T Hori, WC Earnshaw, WC Earnshaw, WH Shang, WH Shang, William C. Earnshaw, X Wan   +39 more
core   +3 more sources

Linezolid prevents fibroblast activation and ameliorates tissue fibrosis by inhibition of mitochondrial translation

Arthritis &Rheumatology, Accepted Article.
Background Beyond its role as a ribosome‐targeting antibiotic, linezolid was recently shown to modulate immune responses by inhibiting mitochondrial translation. Since mitochondrial dysfunction is implicated in various fibrotic diseases, including systemic sclerosis (SSc), this study aimed to evaluate the antifibrotic potential of linezolid and ...
Xuezhi Hong, Yanhua Xiao, Haodong Qi, Shihao Zhu, Tim Filla, Andrea‐Hermina Györfi, Yi‐Nan Li, Meilin Xu, Langxian Zhi, Thuong Trinh‐Minh, Clara Dees, Georg Schett, Jörg H.W. Distler, Alexandru‐Emil Matei   +13 more
wiley   +1 more source

Linear scleroderma following Blaschko′s lines

Indian Journal of Dermatology, Venereology and Leprology, 2005
Blaschko's lines form a pattern, which many diseases are found to follow, but linear scleroderma following Blaschko's lines is a controversial entity rarely reported in the literature. A 24-year-old man presented with multiple linear, atrophic, hyperpigmented lesions punctuated by areas of depigmentations on the left half of the trunk distributed on ...
openaire   +2 more sources

Midline Congenital Cervical Cleft Mimicking Linear Scleroderma

Pediatric Dermatology, 2012
AbstractMidline congenital cervical cleft is an extremely uncommon anomaly of the neck. Fewer than 100 cases have been reported. It is usually described as a cervical scar‐like skin defect. We present a case of midline cervical cleft mimicking linear morphea and treated with topical steroids for 2 years.
Abdulkader Nallib, Ihab, Bautista Casasnovas, Adolfo, Méndez Gallart, Roberto, Estévez Martínez, Elina, Rodríguez Barca, Pablo   +4 more
openaire   +3 more sources

Drugs induced Raynaud's phenomenon and underlying mechanism: a disproportionality analysis from the WHO pharmacovigilance database

Arthritis &Rheumatology, Accepted Article.
Objectives The aim of this study is to generate hypotheses about unknown drugs associated with the onset or worsening of Raynaud's Phenomenon (RP) and to explore their potential pathophysiological mechanisms through a mixed disproportionality/clustering analysis from the WHO pharmacovigilance database.
Alex Hlavaty, Loubna Dari, Jean‐Luc Cracowski, Matthieu Roustit, Charles Khouri   +4 more
wiley   +1 more source

A cooperative release of mitochondrial DNA from platelets and neutrophils drives an interferon signature in systemic sclerosis

Arthritis &Rheumatology, Accepted Article.
Objective Mitochondria are organelles with a hypomethylated circular genome. Mitochondrial DNA (mtDNA) in the systemic circulation has been implicated in inflammation. This study investigates the role of circulating DNA in systemic sclerosis (SSc) and the cellular mechanisms governing its release.
Stavros Giaglis, André N. Tiaden, Simone Häner‐Massimi, Diego Kyburz, Cedric André, Anton Glück, Enrico Ferrero, Stuart Hawtin, Tobias Junt, Ulrich A. Walker   +9 more
wiley   +1 more source

Long‐Term Outcomes of Reduced Intensity Conditioning Hematopoietic Stem Cell Transplantation for Systemic Sclerosis Patients with Impaired Cardiac Function

Arthritis &Rheumatology, Accepted Article.
Objective High intensity conditioning autologous hematopoietic stem cell transplantation (AHSCT) is standard of care for patients with advanced SSc. The role of reduced intensity conditioning (RIC) prior to AHSCT in this population remains unclear. We conducted this study to determine the long‐term outcomes of RIC AHSCT in SSc patients with cardiac ...
Yonatan Lean, Carrie Richardson, Anthony Esposito, Katy Bedjeti, George E. Georges   +4 more
wiley   +1 more source

Cardiopulmonary assessment of patients with systemic sclerosis for hematopoietic stem cell transplantation: recommendations from the European Society for Blood and Marrow Transplantation Autoimmune Diseases Working Party and collaborating partners. [PDF]

, 2017
Systemic sclerosis (SSc) is a rare disabling autoimmune disease with a similar mortality to many cancers. Two randomized controlled trials of autologous hematopoietic stem cell transplantation (AHSCT) for SSc have shown significant improvement in organ ...
A Gabrielli, A-L Hachulla, AJ Tyndall, B Sandmeier, BH Bulkley, C Denton, C Ferri, C Meune, C Meune, C Nannini, CJ Valerio, CS Desai, D C Lee, D Farge, D Farge, D G Kiely, D Launay, D Mukerjee St, DC Lee, DG Kiely, DP Tashkin, E Di Cesare, E Hachulla, E Mousseaux, F Grothues, F van den Hoogen, G Lefèvre, GE Tzelepis, GP Bezante, H Baumgartner, J A Snowden, J Avouac, J de Vries-Bouwstra, J Fransen, J Hurdman, JA Snowden, JC Plana, JD Rich, JG Coghlan, JM van Laar, JPA Ioannidis, JS Arkles, KH Yiu, L Chung, L Scussel-Lonzetti, LG Rudski, M Elhai, M Henein, M Rovira, M-C Oliveira, MC Oliveira, MH Williams, MR Fisher, N Del Papa, N Galiè, NAB Ntusi, P Clements, P de Groote, R Condliffe, R K Burt, R Saccardi, R Saccardi, RA Nishimura, RK Burt, RK Burt, RK Burt, RT Domsic, S Bae, S J Shah, S Jacobsen, S Mavrogeni, SC Mathai, SD Solomon, SJ Shah, SJ Shah, SLF Walsh, T Alexander, T Alexander, WA D’Angelo, WA Zoghbi, Y Allanore, Z Marjanovic   +81 more
core   +1 more source