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Phosphodiesterase-4 inhibition in localized scleroderma: A case series of topical roflumilast [PDF]
SAGE Open Medical Case ReportsLocalized scleroderma, or morphea, is a chronic fibrosing skin condition with limited therapeutic options, particularly for patients who are elderly, immunocompromized, or intolerant to systemic immunosuppressants.
Ghassan Barnawi +4 more
doaj +2 more sources
Immunopathogenesis of Pediatric Localized Scleroderma [PDF]
Frontiers in Immunology, 2019 Localized scleroderma (LS) is a complex disease characterized by a mixture of inflammation and fibrosis of the skin that, especially in the pediatric population, also affects extracutaneous tissues ranging from muscle to the central nervous system ...
Kathryn S. Torok +11 more
doaj +3 more sources
Human MAGI1 expression in endothelial cells protects from the development of localized and systemic scleroderma in mice [PDF]
Arthritis Research & TherapyBackground Systemic sclerosis and localized scleroderma are rheumatoid fibrotic diseases characterized by altered blood vessel permeability and dysregulated angiogenesis.
Oriana Coquoz +6 more
doaj +2 more sources
Revealing Microvascular Involvement in Pediatric Localized Scleroderma Through Nailfold Capillaroscopy [PDF]
ChildrenBackground/Objectives: Juvenile localized scleroderma (jLoS) is a chronic inflammatory disorder with skin and subcutaneous tissue involvement. Microvascular alterations are thought to contribute to its pathogenesis.
Sema Nur Taşkın +5 more
doaj +2 more sources
Localized scleroderma: clinical spectrum and therapeutic update [PDF]
Anais Brasileiros de Dermatologia, 2015 Scleroderma is a rare connective tissue disease that is manifested by cutaneous sclerosis and variable systemic involvement. Two categories of scleroderma are known: systemic sclerosis, characterized by cutaneous sclerosis ...
Mariana Figueiroa Careta, Ricardo Romiti
doaj +2 more sources
Clinical periodontal diagnosis
Periodontology 2000, EarlyView., 2023 Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi +5 more
wiley +1 more source
Вопросы современной педиатрии, 2020 The localized scleroderma (morphea) is the clinical option of the juvenile scleroderma, the third in prevalence rheumatic condition in pediatrics. The article summarizes all the data on the classification, diagnostics, and differential diagnosis of ...
Rinat K. Raupov +2 more
doaj +1 more source
Localized scleroderma in children
Przegląd Dermatologiczny, 2020 Localized scleroderma is an autoimmune disease affecting the dermis and underlying tissues (subcutaneous tissue, fascia, muscles, bones). The disease mainly occurs in women aged 20–50 years; however, children aged 7–10 years represent about 15% of all ...
Katarzyna A. Wolska-Gawron +1 more
doaj +1 more source
Detection of autoimmune antibodies in localized scleroderma by synthetic oligonucleotide antigens. [PDF]
PLoS ONE, 2018 In this study, we developed a series of synthetic oligonucleotides that allowed us to investigate the details on the antigen recognition by autoimmune antibodies in localized scleroderma subjects.
Simone Samuelsen +4 more
doaj +1 more source
Systemic sclerosis with keloidal nodules [PDF]
Anais Brasileiros de Dermatologia, 2013 Nodular sclerosis is a rare form of presentation related to both systemic and localized forms of scleroderma. We describe the case of a patient with nodular sclerosis in order to alert the medical community to recognize this entity.
Bárbara Stadler +4 more
doaj +1 more source