Results 41 to 50 of about 471,570 (210)

Nail Disorders in Systemic Conditions

JEADV Clinical Practice, EarlyView.
ABSTRACT Nail findings in children can be indicative of an underlying systemic disease. Many of these findings are seen in multiple entities and are not specific to one disease. The importance of specifically examining for these nail changes cannot be overstated.
Jane Sanders Bellet
wiley   +1 more source

Case of localized scleroderma associated with osteomyelitis. [PDF]

, 2010
We report a 4-year-old girl presenting with progressive linear scleroderma affecting the right leg. Biopsy specimen disclosed typical histopathological findings of localized scleroderma. Right leg magnetic resonance imaging (MRI) showed high signal areas
Ogawa, Fumihide, Eiji MUROI, Fumiko SUEYOSHI, Toshifumi YAMAOKA, Shinichi SATO, Sueyoshi, Fumiko, Muroi, Eiji, Yamaoka, Toshifumi, Sato, Shinichi, Fumihide OGAWA   +9 more
core   +1 more source

Adult-onset en coup de sabre scleroderma in a patient with linear localized scleroderma profunda: A case report and literature review

SAGE Open Medical Case Reports, 2021
The en coup de sabre variant of linear scleroderma typically occurs in children. We report a unique case of adult-onset en coup de sabre scleroderma in a patient with linear localized scleroderma profunda.
Roxana Mititelu, Zainab Ridha, Lydia Ouchene, Elena Netchiporouk   +3 more
doaj   +1 more source

Paediatric Melanonychia: Diagnosis and Management

JEADV Clinical Practice, EarlyView.
ABSTRACT Longitudinal melanonychia (LM) in children presents unique diagnostic and management challenges that cannot be adequately addressed by applying adult‐based criteria. Unlike in adults, there are no validated clinical, dermoscopic or histopathologic criteria for predicting nail unit melanoma in the paediatric population.
Angela J. Jiang, Erika Koh, Je‐Ho Mun, Dong‐Youn Lee, Matilde Iorizzo, Adam I. Rubin   +5 more
wiley   +1 more source

Management of Non‐Plaque‐Induced Gingival Conditions: A Systematic Review—Part 2: Inflammatory and Immune Conditions; Neoplasms; and Gingival Pigmentation

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aims This systematic review assesses current evidence on the management of non‐plaque (dental biofilm)‐induced gingival diseases and conditions (NPIGDs), including (i) inflammatory and immune conditions, (ii) neoplasms and (iii) gingival pigmentations.
Maria Clotilde Carra, Cecile Wasielewski, Bruno Špiljak, Maja Sabalić‐Schoener, Sebastien Jungo, Ivan Alajbeg   +5 more
wiley   +1 more source

Assessing mature and immature collagen in tonsillar tissue using second harmonic generation microscopy

Journal of Microscopy, EarlyView.
Abstract Recurrent tonsillitis (RT) and obstructive sleep apnoea (OSA) are major indications for tonsillectomy, yet their tissue‐level pathology remains unclear. Recurrent inflammation in RT may induce collagen remodelling through excess extracellular matrix deposition.
Kay Polland, Megan Clapperton, Thushitha Kunanandam, Catalina D Florea, Catriona M Douglas, Gail McConnell   +5 more
wiley   +1 more source

High-content Image-based Drug Testing of Patients’ Primary Fibroblasts Reveals Potential New Treatment Options for Localized Scleroderma

Acta Dermato-Venereologica
Localized scleroderma is a rare autoimmune disease characterized by progressive fibrosis of the skin and its underlying structures, causing loss of normal tissue structure and function.
Katariina Mähönen, Isabel Mogollon, Antti Hassinen, Minttu Polso, Katja Välimäki, Swapnil Potdar, Al-Amin Chowdhury, Annamari Ranki, Jani Saarela, Vilja Pietiäinen, Jaana Panelius   +10 more
doaj   +1 more source

Endpoints and outcomes for localized scleroderma/morphea: a scoping literature review

Pediatric Rheumatology Online Journal
Background Current treatment for localized scleroderma (LS) has been shown to halt disease activity, but little is still known about patient experiences with these treatments, nor is there consensus about optimal measurement strategies for future ...
Alexy Hernandez, Leslie Zapata Leiva, Maria Mutka, Kathryn S. Torok, Leila Ledbetter, Christina K. Zigler   +5 more
doaj   +1 more source

Clinical Profile of Methotrexate-resistant Juvenile Localised Scleroderma

Acta Dermato-Venereologica, 2019
Methotrexate has demonstrated its efficiency for the treatment of juvenile localized scleroderma but some patients may be resistant. The aim of our study was to define the profile of such patients.
Juliette Hardy, Franck Boralevi, Stéphanie Mallet, Natalia Cabrera, Alexandre Belot, Alice Phan, Sébastien Barbarot, Audrey Duriez-Lasek, Christine Chiaverini, Thomas Hubiche, Emmanuel Mahé, Edouard Bégon, Emmanuelle Bourrat, Olivia Boccara, Hélène Aubert, Martine Grall Lerosey, Catherine Droitcourt, Maryam Piram, Juliette Mazereeuw-Hautier, Research Group of the French Society of Paediatric Dermatology (SDFP in French)   +19 more
doaj   +1 more source

Two‐Photon Fluorescence and Second‐Harmonic Generation Microscopy: Principles and Biomedical Applications

Journal of Biophotonics, Volume 19, Issue 10, October 2026.
Compared with single‐photon methods, TPM enables deep‐tissue imaging using near‐infrared light, with excitation confined to the focal plane, thereby reducing photodamage. SHG microscopy images noncentrosymmetric biological structures such as collagen and myosin without fluorescent labels, offering direct structural contrast.
Kausalya Neelavara Makkithaya, Gagan Raju, Subir Das, Ajeetkumar Patil, Rajesh Kumar, Yury V. Kistenev, Guan‐Yu Zhuo, Nirmal Mazumder   +7 more
wiley   +1 more source