Results 61 to 70 of about 9,808 (225)

Craniofacial linear scleroderma associated with retinal telangiectasia and exudative retinal detachment

, 2017
Linear scleroderma is a characteristic form of scleroderma that typically affects children. Ocular manifestations may be present, especially when the frontoparietal area of the head is affected.
Vassallo, Grace, Kehdi, Elias, Ashworth, Jane L., Chieng, S. E Alice, Lenassi, Eva   +4 more
core   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

Advanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian, Yanrui Yang, Qiuyu Li, Ying Hu, Qin Hu, Shasha Ran, Siyu Zhou, Xiujuan Yang, Shanshan Li, Qixiong Zhang   +9 more
wiley   +1 more source

Experience with Lipofilling in Children with Localized Scleroderma: Case Study

Вопросы современной педиатрии
Background. Localized scleroderma (LS) is an inflammatory sclerosing disease of unknown etiology. It is characterized by progressive lesion of connective tissue leading to sclerosis and/or atrophy of the skin and underlying tissues.
Alina R. Misbakhova, Nataliya E. Manturova, Larisa S. Kruglova, Nikolay N. Murashkin, Sofiya R. Mayransaeva   +4 more
doaj   +1 more source

Expresión del factor ? transformador del crecimiento (TGF-?) y del factor de crecimiento derivado de las plaquetas (PDFG) en la esclerodermia lineal

Biomédica: revista del Instituto Nacional de Salud, 2003
La esclerodermia lineal (EL) es una forma localizada de la enfermedad, caracterizada por la proliferación fibroblástica y los infiltrados linfocitarios perivasculares en la dermis.
José Félix Restrepo, Renato Guzmán, Gerzaín Rodríguez, Antonio Iglesias   +3 more
doaj   +1 more source

Interstitial Lung Disease in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: A European Multicenter Study

Arthritis &Rheumatology, EarlyView.
Objective Interstitial lung disease (ILD) can occur in association with antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV‐ILD) or as an isolated entity with positive ANCA (ANCA‐ILD). However, data on the epidemiology and outcomes of these conditions remain limited.
Aglaia Chalkia, Marusa Kotnik, Timothy J. Sadler, Spyridon Katechis, Rachel Jones, Ajay Kamath, Aladdin J. Mohammad, Sara Monti, Chetan Mukhtyar, Viral Nanda, Ioannis Petrakis, Dimitrios Petras, Ashnish Sinha, Pasupathy Sivasothy, Rona Smith, Kostas Stylianou, Dimitrios Vassilopoulos, Judith Babar, David Jayne   +18 more
wiley   +1 more source

Case Reports- Linear scleroderma following Blaschko's lines

, 2005
Blaschko′s lines form a pattern, which many diseases are found to follow, but linear scleroderma following Blaschko′s lines is a controversial entity rarely reported in the literature.
Amiya Kumar Mukhopadhyay
core   +1 more source

Incidence of childhood linear scleroderma and systemic sclerosis in the UK and Ireland.

, 2010
OBJECTIVE: Childhood scleroderma encompasses a rare, poorly understood spectrum of conditions. Our aim was to ascertain the incidence of childhood scleroderma in its different forms in the UK and Ireland, and to describe the age, sex, and ethnicity of ...
Herrick, Ariane L., Baildam, Eileen M., Ennis, Holly, Silman, Alan J., Bhushan, Monica   +4 more
core   +1 more source

Methotrexate in Linear Scleroderma: Long-Term Efficacy in Fifty Children From a Single Pediatric Rheumatology Center

, 2021
Objective: To study disease course and long-term outcome in children with linear scleroderma (SSc) treated with methotrexate (MTX) since diagnosis. Methods: The present study was retrospective and cross-sectional and included consecutive children with ...
Fadanelli G., Martini G., Agazzi A., Vittadello F., Meneghel A., Zulian F.   +5 more
core   +1 more source

Long Noncoding RNA H19 Mediates STAT3‐Dependent Activation of Keratinocytes and Fibroblasts in Systemic Sclerosis Skin

Arthritis &Rheumatology, EarlyView.
Objective Dermal systemic sclerosis (SSc) fibroblasts and their exosomes can activate keratinocytes in SSc, with long noncoding RNA (lncRNA) H19 highlighted as the most up‐regulated RNA in their cargo compared with healthy controls (HCs). The role of H19 in SSc pathogenesis has never been investigated.
Begoña Caballero‐Ruiz, Christopher W. Wasson, Rebecca L. Ross, Francesco Del Galdo   +3 more
wiley   +1 more source