Results 61 to 70 of about 3,196,729 (227)

Expresión del factor ? transformador del crecimiento (TGF-?) y del factor de crecimiento derivado de las plaquetas (PDFG) en la esclerodermia lineal

Biomédica: revista del Instituto Nacional de Salud, 2003
La esclerodermia lineal (EL) es una forma localizada de la enfermedad, caracterizada por la proliferación fibroblástica y los infiltrados linfocitarios perivasculares en la dermis.
José Félix Restrepo, Renato Guzmán, Gerzaín Rodríguez, Antonio Iglesias   +3 more
doaj   +1 more source

Development of Patient‐Reported Outcome Measures for Early Systemic Sclerosis Across Disease Subtypes

Arthritis Care &Research, Accepted Article.
Objective Existing patient‐reported outcome (PRO) measures for systemic sclerosis (SSc) have important limitations, including inadequate coverage of early disease and limited inclusion of diffuse cutaneous (dcSSc) and limited cutaneous (lcSSc) subtypes.
George J. Greene, Chelsea Rose Perschon, Emilie Jaeger, Alain Lescoat, David Cella, Dinesh Khanna   +5 more
wiley   +1 more source

CLINICAL SIGNIFICANCE OF EXTRACORPOREAL PHOTOCHEMOTHERAPY IN COMPLEX TREATMENT OF LOCALIZED SCLERODERMA

Alʹmanah Kliničeskoj Mediciny, 2016
Background: Scleroderma is an autoimmune disease with progressing lesions of connective tissue where fibrosclerotic and vascular disturbances prevail.
O. A. Fomina, A. V. Molochkov, A. V. Kil’dyushevsky   +2 more
doaj   +1 more source

Case of localized scleroderma associated with osteomyelitis. [PDF]

, 2010
We report a 4-year-old girl presenting with progressive linear scleroderma affecting the right leg. Biopsy specimen disclosed typical histopathological findings of localized scleroderma. Right leg magnetic resonance imaging (MRI) showed high signal areas
Ogawa, Fumihide, Eiji MUROI, Fumiko SUEYOSHI, Toshifumi YAMAOKA, Shinichi SATO, Sueyoshi, Fumiko, Muroi, Eiji, Yamaoka, Toshifumi, Sato, Shinichi, Fumihide OGAWA   +9 more
core   +1 more source

Layer‐Specific Dermal and Subcutaneous Delivery via Modular LNP–Hydrogel‐Integrated Threaded Microneedles

Advanced Science, EarlyView.
Guided by spatial transcriptomics and clinical validation, a threaded microneedle platform enables precise layer‐specific delivery across the dermis and subcutaneous tissue. By addressing distinct pathogenic remodeling in different skin layers, this strategy coordinates compartment‐specific intervention, restores tissue architecture, and offers a ...
Fangzhou Xie, Yixiang Zhang, Shifeng Ling, Yuxuan Huang, Yingying Wei, Rao Fu, Jiahao He, Baikun Liu, Lucia Zhou, Kaifeng Huo, Yida Wang, Qingfeng Li, Yawei Du, Wenguo Cui, Yun Xie   +14 more
wiley   +1 more source

Parry-Romberg Syndrome Associated with Localized Scleroderma

Case Reports in Neurology, 2010
Parry-Romberg syndrome is a rare neurocutaneous disorder of unknown origin. It is characterized by progressive facial hemiatrophy and frequently overlaps with a condition known as linear scleroderma ‘en coup de sabre’.
Jelena Maletic, Vassiliki Tsirka, Panos Ioannides, Dimitrios Karacostas, Nikolaos Taskos   +4 more
doaj   +1 more source

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Craniofacial linear scleroderma associated with retinal telangiectasia and exudative retinal detachment

, 2017
Linear scleroderma is a characteristic form of scleroderma that typically affects children. Ocular manifestations may be present, especially when the frontoparietal area of the head is affected.
Vassallo, Grace, Kehdi, Elias, Ashworth, Jane L., Chieng, S. E Alice, Lenassi, Eva, Alice S. Chieng, Jane L. Ashworth, Grace Vassallo, Elias Kehdi, Eva Lenassi   +9 more
core   +1 more source

Treatment in Juvenile Scleroderma

, 2020
Purpose of Review: Treatment of scleroderma in children is challenging since little is known about its pathogenesis. Herein, we review the most recent evidence regarding the treatment of juvenile scleroderma.
Tirelli F., Zulian F.
core   +1 more source

Abatacept Reduces CD319+ (SLAMF7) Cytotoxic T Cells and Cytokine Production in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic sclerosis (SSc) is characterized by immune dysregulation and fibrosis. We investigated whether abatacept modulates CD319/SLAMF7‐expressing cytotoxic T cells implicated in diffuse cutaneous SSc. Methods In this ancillary ASSET trial analysis, peripheral blood mononuclear cells from 67 participants were analyzed at baseline and months ...
Mikel Gurrea‐Rubio, Laura A. Cooney, Kohei Maeda, Phillip L. Campbell, Qi Wu, Camila I. Amarista, Alexander Stinson, Ray Ohara, Yang Mao‐Draayer, Michael L. Whitfield, Shiv Pillai, Poulami Dey, Johann E. Gudjonsson, Pei‐Suen Tsou, Dinesh Khanna, David A. Fox   +15 more
wiley   +1 more source