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Tutorial on modelling chromatographic surrogation of biological processes
Journal of Chromatography OpenThe accurate emulation of biological partition systems through physicochemical models is crucial in pharmacology, toxicology, and environmental science for understanding the ADMET profiles of substances.
Elisabet Fuguet, Martí Rosés
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Oligorotaxane radicals under orders [PDF]
, 2016 A strategy for creating foldameric oligorotaxanes composed of only positively charged components is reported. Threadlike components-namely oligoviologens-in which different numbers of 4,4'-bipyridinium (BIPY(2+)) subunits are linked by p-xylylene bridges,
Botros, Youssry Y +9 more
core +6 more sources
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Natural Product Communications, 2013 The flavonoids are a structurally diverse class of natural products that exhibit a broad spectrum of biochemical activities. The flavones are one of the most studied flavonoid subclasses due to their presence in dietary plants and their potential to ...
William L. Whaley +6 more
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A linear solvation energy relationship to predict vapor pressure from molecular structure [PDF]
Journal of the Brazilian Chemical Society, 2005 Vapor pressures (in Pa at 298 K) of organic liquids were found to correlate (R2 = 0.986) with empirical molecular parameters by the relationship: log Pvap = 7.86 - 3.54 V - 1.17 E - 1.52 (S + l) - 3.64 (h × A × B) where V, E, S, A, and B are solute parameters developed by Abraham and coworkers representing, respectively, the characteristic volume ...
Quina, Frank H. +2 more
openaire +3 more sources
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
, 2008 Due to solvation, excess charge carriers on 1d semiconductor nanostructures immersed in polar solvents undergo self-localization into polaronic states. Using a simplified theoretical model for small-diameter structures, we study low-frequency properties ...
Alexandrov +32 more
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FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Solvent effect on electronic absorption spectra of some N-aryl substituted dodekanamides
Macedonian Journal of Chemistry and Chemical Engineering, 2006 A series of N-aryl substituted dodekanamides were synthesized using the reaction of fatty acid chloride (lauroylchloride) with p-substituted aromatic amines in the presence of triethylamine as an organic base and dioxane as a solvent. The structures of N-
Viktorija Stamatovska +2 more
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