Results 91 to 100 of about 15,284 (214)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Local Tropical Linear Spaces [PDF]

Discrete & Computational Geometry, 2013
In this paper we study general tropical linear spaces locally: For any basis B of the matroid underlying a tropical linear space L, we define the local tropical linear space L_B to be the subcomplex of L consisting of all vectors v that make B a basis of maximal v-weight.
openaire   +3 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Automated linear buckling analysis of space frame structures

Results in Engineering
This article presents a streamlined procedure for assessing the capacity of space frame structures by incorporating geometric (stress) stiffness directly into the structural analysis.
Munib Sarwar, Bjørn Melhus
doaj   +1 more source

Linear differential equations with coefficients in Fock type space

Electronic Journal of Qualitative Theory of Differential Equations, 2011
In this paper we deal with complex differential equations of the form \begin{eqnarray*} f^{(k)}+a_{k-1}(z)f^{(k-1)}+\cdot\cdot\cdot+a_{1}(z)f^{'}+a_{0}(z)f=0 \end{eqnarray*} with the coefficients in Fock type space.
Xiang Dong Yang, Jin Tu
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A Linear Composition Operator on the Bloch Space

Mathematics
Let n∈N0, ψ be an analytic self-map on D and u be an analytic function on D. The single operator Du,ψn acting on various spaces of analytic functions has been a subject of investigation for many years.
Xiangling Zhu, Qinghua Hu
doaj   +1 more source

Linear algebra and differential geometry on abstract Hilbert space

International Journal of Mathematics and Mathematical Sciences, 2005
Isomorphisms of separable Hilbert spaces are analogous to isomorphisms of n-dimensional vector spaces. However, while n-dimensional spaces in applications are always realized as the Euclidean space Rn, Hilbert spaces admit various useful realizations as ...
Alexey A. Kryukov
doaj   +1 more source