Results 81 to 90 of about 15,284 (214)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Incremental Local Linear Fuzzy Classifier in Fisher Space
EURASIP Journal on Advances in Signal Processing, 2009 Optimizing the antecedent part of neurofuzzy system is an active research topic, for which different approaches have been developed. However, current approaches typically suffer from high computational complexity or lack of ability to extract knowledge ...
Armin Eftekhari +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A Cubic Set Theoretical Approach to Linear Space
Abstract and Applied Analysis, 2015 The main motivation of this paper is to introduce the notion of cubic linear space. This inspiration is received from the structure of cubic sets. The notions of R-intersection, R-union, P-intersection, and P-union of cubic linear spaces are defined and ...
S. Vijayabalaji, S. Sivaramakrishnan
doaj +1 more source
Advancing brain-machine interfaces: Moving beyond linear state space models
Frontiers in Systems Neuroscience, 2015 Advances in recent years have dramatically improved output control by Brain-Machine Interfaces (BMIs). Such devices nevertheless remain robotic and limited in their movements compared to normal human motor performance.
Adam G Rouse +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Linear space string correction algorithm using the Damerau-Levenshtein distance
BMC Bioinformatics, 2020 Background The Damerau-Levenshtein (DL) distance metric has been widely used in the biological science. It tries to identify the similar region of DNA,RNA and protein sequences by transforming one sequence to the another using the substitution, insertion,
Chunchun Zhao, Sartaj Sahni
doaj +1 more source
Numerical Linear Algebra in Linear Space
52 pages, 0 ...
Yiping Liu, Hoai-An Nguyen, Junzhao Yang
openaire +2 more sources