Results 41 to 50 of about 10,463 (261)

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Linear Maps that Preserve Any Two Term Ranks on Matrix Spaces over Anti-Negative Semirings

open access: yesMathematics, 2020
There are many characterizations of linear operators from various matrix spaces into themselves which preserve term rank. In this research, we characterize the linear maps which preserve any two term ranks between different matrix spaces over anti ...
Kyung Tae Kang   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

On saturation of one linear method for summing Fourier series given by a function set

open access: yesResearches in Mathematics
The paper considers the issues of saturation in the spaces $C$ and $L_p$, $p\in [1;\infty )$ of the biharmonic Poisson operator, in particular, the order and class of saturation are found.
A.M. Shutovskyi, Yu.I. Kharkevych
doaj   +1 more source

More on the extension of linear operators on Riesz spaces

open access: yesKarpatsʹkì Matematičnì Publìkacìï, 2022
The classical Kantorovich theorem asserts the existence and uniqueness of a linear extension of a positive additive mapping, defined on the positive cone $E^+$ of a Riesz space $E$ taking values in an Archimedean Riesz space $F$, to the entire space $E$.
O.G. Fotiy, A.I. Gumenchuk, M.M. Popov
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Properties of Fuzzy Closed Linear Operator [PDF]

open access: yesEngineering and Technology Journal, 2019
In this paper we recall the definition of fuzzy norm of a fuzzy bounded linear operator and the fuzzy convergence of sequence of fuzzy bounded linear operators in order to prove the uniform fuzzy bounded theorem and fuzzy open mapping theorem.
Jehad Kider, Noor Kadhum
doaj   +1 more source

Approximation of Linear Operators on a Weiner Space

open access: yesRocky Mountain Journal of Mathematics, 1986
We study optimal algorithms and optimal information in an average case model for linear problems in a Wiener space. We show that a linear algorithm is optimal among all algorithms. We illustrate the theory by interpolation, integration and approximation. We prove that adaption does not help.
openaire   +4 more sources

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

C0-semigroups of linear operators on some ultrametric Banach spaces

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2006
C0-semigroups of linear operators play a crucial role in the solvability of evolution equations in the classical context. This paper is concerned with a brief conceptualization of C0-semigroups on (ultrametric) free Banach spaces E.
Toka Diagana
doaj   +1 more source

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