LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Walking with wider steps changes foot placement control, increases kinematic variability and does not improve linear stability. [PDF]
R Soc Open Sci, 2017 Perry JA, Srinivasan M.
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Robust stability of patterned linear systems
Electronic Journal of Differential Equations, 2013 For a Hurwitz stable matrix $A\in \mathbb{R}^{n\times n}$, we calculate the real structured radius of stability for $A$ with a perturbation $P=B\Delta (t)C$, where $A, B, C$, $ \Delta (t)$ form a patterned quadruple of matrices; i.e., they are ...
Henry Gonzalez
doaj
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Exact solitary wave solutions and linear stability of the β-time-fractional Gardner equation in shallow water dynamics. [PDF]
Sci ProgElsaid Ramadan M +4 more
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GraTeLPy: graph-theoretic linear stability analysis. [PDF]
BMC Syst Biol, 2014 Walther GR, Hartley M, Mincheva M.
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Linear Stability of Schwarzschild-Anti-de Sitter Spacetimes III: Quasimodes and Sharp Decay of Gravitational Perturbations. [PDF]
Commun Math PhysGraf O, Holzegel G.
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